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Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...

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Breast Cancer Resistance Protein (BCRP)<br />

A new member <str<strong>on</strong>g>of</str<strong>on</strong>g> <strong>ABC</strong> transporter superfamily;<br />

Also known as <strong>ABC</strong>P (<strong>ABC</strong> transporter in placenta),<br />

MXR (mitoxantr<strong>on</strong>e-resistance protein)<br />

<strong>ABC</strong>G2 (the 2nd family <str<strong>on</strong>g>of</str<strong>on</strong>g> <strong>ABC</strong> subgroup G)<br />

Broad substrate specificity;<br />

mitoxantr<strong>on</strong>e, topoisomerase I inhibitors, methotrexate, topotecan<br />

zidovudine, lamivudine, flavopiridol, sulfate c<strong>on</strong>jugates, omeprazole<br />

genistein

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