Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...

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Mitoxantrone Accumulation In MCF-7 Cells 600 500 400 300 200 100 0 *** *** *** *** ∗∗∗ *** *** *** *** *** *** ∗∗∗ ∗∗∗ * * *** *** control apigenin Biochanin A chrysin daidzein EGC EGCG fisetin genistein hesperetin kaempferol luteolin morin myricetin naringenin naringin phloretin phloridzin quercetin silybin silymarin FTC MCF-7/sensitive (-BCRP) MCF-7 MX100 (+BCRP) Mitoxantrone: 3 µM <strong>Flavonoid</strong>: 50 µM N = 6 or 7 MX accumulation (% <strong>of</strong> control)
Correlation Between MX Accumulation In H460 MX20 and MCF-7 MX100 Cells Accumultion in MCF-7 MX100 500 400 300 200 100 0 0 100 200 300 400 500 Accumulation in H460 MX20 R 2 =0.74, p < 0.05
Page 1 and 2: Flavonoid-
Page 3 and 4: Flavonoids ‣ Epi
Page 5 and 6: Flavonoid Products
Page 7 and 8: Flavonoid Products
Page 9 and 10: Hepatocyte OCT1 SMALL ORGANIC CATIO
Page 11 and 12: ABC Transporter Expression in the L
Page 13 and 14: General Study Design ‣ In vitro s
Page 15 and 16: Increase of 3 H-DN
Page 17 and 18: Flavonoid-P-gp <st
Page 19 and 20: Flavonoid-
Page 21 and 22: Multidrug Resistance-Associated Pro
Page 23 and 24: Flavonoids increas
Page 25 and 26: Inhibitory constants for 3 H-LTC4 t
Page 27 and 28: Breast Cancer Resistance Protein (B
Page 29 and 30: BCRP Clinical Implications • Appa
Page 31: Investigated Flavonoid</str
Page 35 and 36: Combined Effects <
Page 37 and 38: Dose-Response Prof
Page 39 and 40: Berenbaum’s Interaction Index Met
Page 41 and 42: Conclusions Flavonoid</str
Page 43 and 44: Effect of GF120918
Page 45 and 46: Effect of Chrysin
Page 47 and 48: Effect of 7,8-benz
Page 49 and 50: Effect of
Page 51 and 52: Effect of
Page 53: Flavonoid

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