Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...

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ABC Proteins • ATP binding cassette (ABC) superfamily P-glycoprotein (MDR1, ABCB1) Multidrug Resistance Associated Proteins (MRP, ABCC) Breast Cancer Resistance Protein (BCRP, ABCG2) • Efflux molecules out <strong>of</strong> cells • Tumor → multi-drug resistance • Present in the liver, kidney, BBB, gastrointestinal tract where important for drug disposition in out
Hepatocyte OCT1 SMALL ORGANIC CATIONS OAT ORGANIC ANIONS MONOVALENT BILE SALTS NTCP BULKY ORGANIC COMPOUNDS OATP GSH E R MDR1 MRP 2 MRP 2 MRP 3 MRP1 MDR3 PHOSPHATIDYL - CHOLINE MRP 6 BSEP/SPGP BCRP ©MM 98 NTCP MONOVALENT BILE SALTS Michael Müller
Page 1 and 2: Flavonoid-
Page 3 and 4: Flavonoids ‣ Epi
Page 5 and 6: Flavonoid Products
Page 7: Flavonoid Products
Page 11 and 12: ABC Transporter Expression in the L
Page 13 and 14: General Study Design ‣ In vitro s
Page 15 and 16: Increase of 3 H-DN
Page 17 and 18: Flavonoid-P-gp <st
Page 19 and 20: Flavonoid-
Page 21 and 22: Multidrug Resistance-Associated Pro
Page 23 and 24: Flavonoids increas
Page 25 and 26: Inhibitory constants for 3 H-LTC4 t
Page 27 and 28: Breast Cancer Resistance Protein (B
Page 29 and 30: BCRP Clinical Implications • Appa
Page 31 and 32: Investigated Flavonoid</str
Page 33 and 34: Correlation Between MX Accumulation
Page 35 and 36: Combined Effects <
Page 37 and 38: Dose-Response Prof
Page 39 and 40: Berenbaum’s Interaction Index Met
Page 41 and 42: Conclusions Flavonoid</str
Page 43 and 44: Effect of GF120918
Page 45 and 46: Effect of Chrysin
Page 47 and 48: Effect of 7,8-benz
Page 49 and 50: Effect of
Page 51 and 52: Effect of
Page 53: Flavonoid

Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...

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