Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
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Effect <str<strong>on</strong>g>of</str<strong>on</strong>g> Chrysin <strong>on</strong> Topotecan PK<br />
in mdr1a/1b (-/-) mice<br />
Animal: mdr1a/1b (-/-) mice (23~26.5 g)<br />
Dosing regimen:<br />
C<strong>on</strong>trol: vehicle: olive oil, oral<br />
Treatment: 50 mg/kg chrysin, oral<br />
3 min later, topotecan 2mg/kg, oral<br />
(in saline c<strong>on</strong>taining 5% glucose)<br />
Topotecan plasma<br />
c<strong>on</strong>centrati<strong>on</strong> (ng/ml)<br />
100 c<strong>on</strong>trol<br />
50 mg/kg chrysin<br />
10<br />
1<br />
0.1<br />
0 100 200 300 400<br />
Time (min)<br />
Parameters<br />
C<strong>on</strong>trol (n=4)<br />
Chrysin (50mg/kg)<br />
(n=4)<br />
AUC 0-360<br />
(ng/ml·min) 4.56 ± 3.95 (×10 3 ) 4.17 ± 2.93 (×10 3 )<br />
AUC 0-∞<br />
(ng/ml·min) 5.01 ± 3.96 (×10 3 ) 4.65 ± 2.98 (×10 3 )<br />
Tmax (min) 45.0 ± 46.4 33.7 ± 18.9<br />
Cmax (ng/ml) 45.2 ± 47.3 50.8 ± 45.8<br />
terminal T1/2 (min) 63.6 ± 42.7 90.6 ± 20.5
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