Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
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<str<strong>on</strong>g>Flav<strong>on</strong>oid</str<strong>on</strong>g> <str<strong>on</strong>g>Interacti<strong>on</strong>s</str<strong>on</strong>g> with <strong>ABC</strong><br />
Transporters<br />
‣<str<strong>on</strong>g>Flav<strong>on</strong>oid</str<strong>on</strong>g>s are widely-present in food and herbal products.<br />
‣Inhibitory interacti<strong>on</strong>s occur with P-glycoprotein, MRP1 and<br />
BCRP. These interacti<strong>on</strong>s may be beneficial for the reversal <str<strong>on</strong>g>of</str<strong>on</strong>g><br />
multidrug resistance in cancer. <str<strong>on</strong>g>Flav<strong>on</strong>oid</str<strong>on</strong>g>s may also increase the<br />
bioavailability and decrease the clearance <str<strong>on</strong>g>of</str<strong>on</strong>g> drugs.<br />
‣C<strong>on</strong>centrati<strong>on</strong>s achievable in vivo in the gastrointestinal tract are<br />
likely high enough to result in significant interacti<strong>on</strong>s with <strong>ABC</strong><br />
transporters. This is particularly true with respect to flav<strong>on</strong>oid<br />
c<strong>on</strong>centrati<strong>on</strong>s after herbal medicines.
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