Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...

More documents

Recommendations

Info

<strong>Flavonoid</strong>-<strong>Drug</strong> <strong>Interactions</strong> <strong>Flavonoid</strong>-drug interactions could occur upon coadministration but appear to be substrate dependent (and will be flavonoid dependent) However, other factors (for example, other transporters) may be important – there may be poor prediction if only based on their interaction with P-glycoprotein and CYP3A4
Multidrug Resistance-Associated Protein 1 (MRP1, ABCC1) MRP1 is a 190-kDa protein encoded by the MRP1 gene. Expressed in most normal tissues in the human body and in several types <strong>of</strong> tumors such as lung carcinoma, myeloid leukemia, neuroblastoma, and breast cancer Substrates <strong>of</strong> MRP1: • Endogenous substrates: leukotriene C 4 , glutathione disulfide, steroid glucuronides (17β-estradiol 17-β-D-glucuronide) • Exogenous substrates: daunomycin, vinca alkaloid (vinblastine), methotrexate, fluorouracil, chlorambucil, calcein, drug conjugates
Page 1 and 2: Flavonoid-
Page 3 and 4: Flavonoids ‣ Epi
Page 5 and 6: Flavonoid Products
Page 7 and 8: Flavonoid Products
Page 9 and 10: Hepatocyte OCT1 SMALL ORGANIC CATIO
Page 11 and 12: ABC Transporter Expression in the L
Page 13 and 14: General Study Design ‣ In vitro s
Page 15 and 16: Increase of 3 H-DN
Page 17 and 18: Flavonoid-P-gp <st
Page 19: Flavonoid-
Page 23 and 24: Flavonoids increas
Page 25 and 26: Inhibitory constants for 3 H-LTC4 t
Page 27 and 28: Breast Cancer Resistance Protein (B
Page 29 and 30: BCRP Clinical Implications • Appa
Page 31 and 32: Investigated Flavonoid</str
Page 33 and 34: Correlation Between MX Accumulation
Page 35 and 36: Combined Effects <
Page 37 and 38: Dose-Response Prof
Page 39 and 40: Berenbaum’s Interaction Index Met
Page 41 and 42: Conclusions Flavonoid</str
Page 43 and 44: Effect of GF120918
Page 45 and 46: Effect of Chrysin
Page 47 and 48: Effect of 7,8-benz
Page 49 and 50: Effect of
Page 51 and 52: Effect of
Page 53: Flavonoid

Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...

Create successful ePaper yourself

Delete template?

Save as template?