Abstract Directory, Thursday, May 16, 2013 Poster Session I, continued 4:00 PM - 6:00 PM Room: Exhibit Hall C/D Late Breaking Abstracts I 696 HIV Latency: Activating Virus Expression with Combined <strong>Gene</strong>tic and Chemical Tools Suresh K. Arya, PhD, Agnes Holczbauer, MD 697 Sensitisation <strong>of</strong> neuroblastoma cells for TRAIL-induced apoptosis by downregulated XIAP Ahmet Cingoz, Yavuz Taga, Betul Catalgol 698 Abstract Withdrawn from Presentation 699 Culture and cryopreservation <strong>of</strong> human epidermal melanocytes (MC) for preclinical trials Kim Jin Tac, Pak Seoung Hoon, Shin Back Soo, Han Su-Youne, Lee Hyeon Kyeong, Lee Hyun Woo, Kim Ji Hyang, Lee Ai-Young, Do Byung-Rok 700 Universal Stem <strong>Cell</strong> <strong>Gene</strong> <strong>Therapy</strong> Platform: Upgrading the Long-Term <strong>Gene</strong> <strong>Therapy</strong> Arm by shifting from Analogic to Breakthrough Digital Endonuclease- Boosted <strong>Gene</strong> Targeting and Focussing on Next <strong>Gene</strong>ration Ex Vivo Protocols Roger Bertolotti Thursday, May 16, 2013 <strong>Final</strong> <strong>Program</strong> SALT LAKE CITY, UTAH May 15–18, 2013 107
Friday, May 17, 2013 Abstract Directory, Friday, May 17, 2013 Oral Abstract Session 320 DNA Vectorology & <strong>Gene</strong> Targeting 1:00 PM - 3:00 PM Room: Ballroom A 266 1:00 PM <strong>Gene</strong> Targeting at Silent Loci with Adeno-Associated Virus Vectors Li B. Li, David R. Deyle, David W. Russell. 267 1:15 PM Development <strong>of</strong> Novel Adeno-Associated Virus Variants Targeting HIV-Infected T <strong>Cell</strong>s Dawn P. Wooley, John Weinstein, Poornima K. L. Narayan, Priyanka Sharma, David V. Schaffer, Katherine J. D. A. Exc<strong>of</strong>fon. 268 1:30 PM DNA Hairpins Stimulate Eficient <strong>Gene</strong> Correction Via Double Strand Break Repair Matthew L. Hirsch, Richard H. Samulski. 269 1:45 PM A Transposon-Based Inducible System for Improved Expression In Vivo Joseph E. Doherty, Lauren E. Woodard, Adham S. Bear, Aaron Foster, Matthew H. Wilson. 270 2:00 PM Minicircle DNA Is Superior to Plasmid DNA in Eliciting Antigen-Speciic CD8+ T <strong>Cell</strong> Responses and <strong>Gene</strong>rating Protective Immunity Nicole E. B. Skinner, Wynette M. Dietz, Sara E. Hamilton, Michelle D. Jund, Suzanne Heitfeld, Adam J. Litterman, Patrick Hwu, Zhi- Ying Chen, Andres M. Salazar, John R. Ohlfest, Bruce R. Blazar, Christopher A. Pennell, Mark J. Osborn. 271 2:15 PM A Mini-Intronic Plasmid (MIP): A Novel Robust Transgene Expression Vector In Vivo and In Vitro Jiamiao Lu, Feijie Zhang, Mark A. Kay. 272 2:30 PM Vertically-Integrated Translational Studies <strong>of</strong> PDX1 as a Therapeutic Target for Pancreatic Cancer Via a Novel Bifunctional RNAi Platform F. Charles Brunicardi, Juehua Yu, Shi-he Liu, Guisheng Zhou, Robbi Sanchez, Christopher M. Jay, Padmasini Kumar, Phillip B. Maples, Donald D. Rao, Neil Senzer, John Nemunaitis. 273 2:45 PM Phase I Trial <strong>of</strong> Escalating Doses <strong>of</strong> SGT-53 Infusion in Combination with Docetaxel in Advanced Solid Tumor Patients John Nemunaitis, Neil Senzer, Cynthia Bedell, Derek Nemunaitis, Meghan Degele, Gerald Edelman, Minal Barve, Robert Nunan, Kathleen F. Pirollo, Antonina Rait, Esther H. Chang. Oral Abstract Session 321 <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> <strong>of</strong> Diabetes, Metabolic and <strong>Gene</strong>tic Diseases I 1:00 PM - 3:00 PM Room: Ballroom B 274 1:00 PM AAV Integrates Randomly into the Nuclear and Mitochondrial Genome after LPLD <strong>Gene</strong> <strong>Therapy</strong> Christine Kaeppel, Stuart Beattie, Raffaele Fronza, Richard van Logtenstein, Florence Salmon, Sabine Schmidt, Stephan Wolf, Ali Nowrouzi, Hanno Glimm, Christ<strong>of</strong> von Kalle, Harald Petry, Daniel Gaudet, Manfred Schmidt. 275 1:15 PM Ex Vivo Lentiviral <strong>Gene</strong> <strong>Therapy</strong> as a Cure for Murine Pompe Disease Merel Stok, Helen de Boer, Marshall W. Huston, Edwin H. Jacobs, Onno Roovers, Holger Jahr, Dirk J. Duncker, Trudi P. Visser, Ans T. van der Ploeg, Arnold J. J. Reuser, Nico P. van Til, Gerard Wagemaker. 276 1:30 PM Pathogenesis <strong>of</strong> Growth Failure in Murine and Canine Glycogen Storage Disease-Ia and Partial Reversal <strong>of</strong> Growth Failure Using Adeno-Associated Viral Vector <strong>Therapy</strong> Elizabeth J. Brooks, Dianne Little, Ramamani Arumugam, Baodong Sun, Sarah Curtis, Amanda DeMaster, Michael Maranzano, Mark W. Jackson, Priya Kishnani, Michael S. Freemark, Dwight D. Koeberl. 277 1:45 PM AAV-Mediated Direct Somatic <strong>Gene</strong>tic Correction <strong>of</strong> Epidermolysis Bullosa Sandra Melo, Leszek Lisowski, Lisa Bashkirova, Mark A. Kay, Anthony E. Oro. 278 2:00 PM Correction <strong>of</strong> Mitochondrial Cardiomyopathy Associated with Friedreich Ataxia in a Transgenic Model by <strong>Gene</strong> <strong>Therapy</strong> Brahim Belbellaa, Morgane Perdomini, Laurent Monassier, Laurence Reutenauer, Nadia Messaddeq, Ronald G. Crystal, Patrick Aubourg, Hélène Puccio. 279 2:15 PM Integration Proile <strong>of</strong> Lentiviral Vectors in <strong>Gene</strong> <strong>Therapy</strong> for X-Adrenoleukodystrophy Cynthia C. Bartholomae, Nathalie Cartier, Salima Hacein-Bey- Abina, Ina Kutschera, Alain Fischer, Marina Cavazzana-Calvo, Patrick Aubourg, Manfred Schmidt, Christ<strong>of</strong> von Kalle. 280 2:30 PM A Partial Deiciency Model <strong>of</strong> MUT Methylmalonic Acidemia (MMA) Displays Diet Inducible Disease and Sensitivity to Acetaminophen (APAP) Julien S. Senac, Vijay H. Aswani, Justin R. Sysol, Irini Manoli, Charles P. Venditti. 108 <strong>Final</strong> <strong>Program</strong> SALT LAKE CITY, UTAH May 15–18, 2013
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