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Final Program - American Society of Gene & Cell Therapy

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Wednesday, May 15, 2013<br />

Abstract Directory, Wednesday, May 15, 2013<br />

Oral Abstract Session 135<br />

Chemical and Molecular Conjugates<br />

3:15 PM - 4:15 PM<br />

Room: 151 ABCG<br />

41 3:15 PM<br />

Optimized Polyplexes That Avoid Liver Uptake and<br />

Maintain Eficient <strong>Gene</strong> Transfer In Vivo<br />

Sanjib Khargharia, Koby Kizzire, Mark E. Ericson, Nick J.<br />

Baumhover, Kevin G. Rice.<br />

42 3:30 PM<br />

Synergistic Cancer <strong>Therapy</strong> by Simultaneous<br />

Expression and Silencing <strong>of</strong> Pro-Apoptotic and Pro-<br />

Survival <strong>Gene</strong>s Using Chimeric Nanoparticles<br />

Soo Kyung Cho, Jane Kim, Young Jik Kwon.<br />

43 3:45 PM<br />

Examining <strong>Cell</strong>-Penetrating Homochiral Cyclic Peptides<br />

as siRNA Non-Viral Transfection Agents<br />

Christiaan D. King, Ria L. Swanekamp, Bradley L. Nilsson, David A.<br />

Dean.<br />

44 4:00 PM<br />

Structure and Silencing Activity <strong>of</strong> Imidazole-<br />

Containing Peptide siRNA Polyplexes Are Dependent on<br />

Hydrogen Bonding<br />

Szu-Ting Chou, Kellie Hom, Lucas Tricoli, Jason Hustedt, Amy<br />

Lee, Joonil Seog, Jason Kahn, Qixin Leng, Daoning Zhang, Michael<br />

Shapiro, Archibald J. Mixson.<br />

Oral Abstract Session 136<br />

Infectious Diseases and Vaccines<br />

3:15 PM - 4:15 PM<br />

Room: 150 ABC<br />

45 3:15 PM<br />

Inducing Humoral and <strong>Cell</strong>ular Responses to Multiple<br />

Sporozoite and Liver-Stage Malaria Antigens Using<br />

pDNA<br />

Bernadette Ferraro, Kendra T. Talbot, Amritha Balakrishnan,<br />

Matthew P Morrow, Natalie A. Hutnick, Devin J. Myles, Devon J.<br />

Shedlock, Nyamekye Obeng-Adjei, Jian Yan, Rachel Shiver, Amir<br />

S. Khan, Maria Yang, Ami S. Brown, Ulrike Wille-Reece, Ashley<br />

Birkett, Niranjan Y. Sardesai, David B. Weiner.<br />

46 3:30 PM<br />

T-<strong>Cell</strong>s Edited To Express the C34 Peptide from gp41<br />

Heptad Repeat-2 Fused to CCR5 or CXCR4 Exhibit<br />

Robust Protection from Diverse HIV-1 Isolates<br />

Jianbin Wang, George J. Leslie, Jennifer Duong, Kevin L. Hua, Jenny<br />

J. Yan, Beth Haggarty, Andrea P. Jordon, Josephine Romano, Lei<br />

Zhang, Edward J. Rebar, Philip D. Gregory, James A. Hoxie, Michael<br />

C. Holmes.<br />

47 3:45 PM<br />

Integrase-Defective Lentiviral Vector-Induced Dendritic<br />

<strong>Cell</strong>s: Clinical Development and Validation <strong>of</strong> CD4+/<br />

CD8+ T <strong>Cell</strong> Responses for Combination with Adoptive<br />

CMV-Speciic T-<strong>Cell</strong> <strong>Therapy</strong><br />

Anusara Daenthanasanmak, Constanca Figueiredo, Eliana<br />

Ruggiero, Manfred Schmidt, Arnold Ganser, Renata Stripecke.<br />

48 4:00 PM<br />

Engineering Resistance to HIV-1 Infection with a Dual<br />

Therapeutic Lentiviral Vector<br />

Bryan P. Burke, Maureen P. Boyd, Michelle L. Millington, Helen<br />

Impey, Jane Zhang, Maria V. Carroll, Joanna Camba-Colon, Naomi<br />

Keech, Frederic Delebecque, Orit Wolstein, Annett Howe, Rachel<br />

Koldej, Tamara Nicolson, Bernard R. Levin, Valerie Rezek,<br />

Dimitrios N. Vatakis, Scott G. Kitchen, Louis R. Breton, Jeffrey S.<br />

Bartlett, Ge<strong>of</strong>f P. Symonds.<br />

Oral Abstract Session 137<br />

<strong>Cell</strong> Processing and Vector Production<br />

4:20 PM - 5:20 PM<br />

Room: 151 ABCG<br />

49 4:20 PM<br />

gc Cytokines IL7 and IL15 Expanded Chimeric Antigen<br />

Receptor-Redirected T <strong>Cell</strong>s (CAR-T) with Superior<br />

Antitumor Activity In Vivo<br />

Yang Xu, Ming Zhang, Aruna Mahendravada, Barbara Savoldo,<br />

Gianpietro Dotti.<br />

50 4:35 PM<br />

Large-Scale Clinical-Grade Retroviral Vector Production<br />

in iCELLis Nano Bioreactor<br />

Xiuyan Wang, Malgorzata Olzzewska, Jinrong Qu, Teresa<br />

Wasielewska, Shirley Bartido, Gregory Hermetet, Michel Sadelain,<br />

Isabelle Riviere.<br />

51 4:50 PM<br />

Large Scale Production <strong>of</strong> Lentiviral Vectors Using<br />

Serum Free Suspension <strong>Cell</strong> Culture System<br />

Amelia H. Thomas, Kevin Brown, Francis H. Pierciey, Jr, Gabor<br />

Veres, Byoung Y. Ryu.<br />

52 5:05 PM<br />

A Single Baculovirus for the Production <strong>of</strong> rAAV8 Viral<br />

Vectors<br />

Lionel Galibert, Aurélien Jacob, Bérangère Langlet-Bertin,<br />

Marjorie Boutin Fontaine, Delphine Bonnin, Christophe Lecomte,<br />

Christel Rivière, Otto W. Merten.<br />

90<br />

<strong>Final</strong> <strong>Program</strong> SALT LAKE CITY, UTAH May 15–18, 2013

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