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Final Program - American Society of Gene & Cell Therapy

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Abstract Directory, Saturday, May 18, 2013<br />

Saturday, May 18, 2013<br />

Poster Session III, continued<br />

3:45 PM - 5:45 PM<br />

Room: Exhibit Hall C/D<br />

Cancer-Targeted <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>: <strong>Cell</strong><br />

<strong>Therapy</strong> / Immunotherapy / <strong>Cell</strong>ular Targets<br />

654<br />

Combination <strong>of</strong> CD3+CD56+ (NKT) <strong>Cell</strong>s<br />

Immunotherapy and Adenovirus-p53 <strong>Gene</strong> <strong>Therapy</strong> for<br />

Head and Neck Squamous <strong>Cell</strong> Carcinoma<br />

Hiroki Saito, Naoya Morishita, Kyung-Mi Lee, Dante Dator, Masato<br />

Kawabata, Masato Fujisawa, Toshiro Shirakawa.<br />

655<br />

Interfering Peptides Targeting Transcription Factor<br />

AP1 for Pancreatic Cancer <strong>Gene</strong> <strong>Therapy</strong><br />

Soukaina Rejiba, Megan Frelan, Alex Hermann, Katja Arndt, Amor<br />

Hajri.<br />

656<br />

JMJD3 Regulates Senescence-Associated Secretory<br />

Phenotype Factors Responsible for Robust Neural Stem<br />

<strong>Cell</strong> Tropism toward Glioma<br />

Michael E. Silva, Patrick M. Perrigue, Daniel Mota, Lauren Joseph,<br />

Nathan Feng, Michael Reid, Joseph Najbauer, Karen S. Aboody.<br />

657<br />

Bioengineering ACE Synthetic Chromosomes for Anti-<br />

Cancer <strong>Gene</strong> <strong>Therapy</strong><br />

Edward Perkins, Jon Holy, Teresa Rose-Hellkant, Amy Greene.<br />

658<br />

DNA Vaccine with scFv6.C4 Prevent the Growth <strong>of</strong><br />

Tumor Expressing CEA<br />

Priscila M. A. Denapoli, Roberta S. Stilhano, Priscila K. Matsumoto,<br />

Carolina B. Parise, Jane Z. de Moraes, Wolfgang Zimmermann, Sang<br />

W. Han.<br />

659<br />

Presumptive Oncogenic Transcriptional Factor PDX1<br />

Regulates Pancreatic Cancer Via an Ampliication Loop<br />

Involving the RAS, PI3K and p53 Signaling Pathways<br />

Juehua Yu, Guisheng Zhou, Shi-he Liu, James Wu, John Nemunaitis,<br />

Neil Senzer, Donald Rao, Enrique Rosengurt, F. C. Brunicardi.<br />

660<br />

Targeting Lysosome Integrity as a Method To Restore<br />

Sensitivity to Ceramide-Induced <strong>Cell</strong> Death<br />

Lorianne S. Turner, Krissy Smith, Lenton Holley, Christopher<br />

Johnson, Timothy Prince, Heather Yancey.<br />

Hematologic and Immunologic <strong>Gene</strong> & <strong>Cell</strong><br />

<strong>Therapy</strong> II<br />

661<br />

Lentiviral <strong>Gene</strong> <strong>Therapy</strong> <strong>of</strong> RAG Severe Combined<br />

Immunodeiciency<br />

Niek P. van Til, Guus van der Velden, Helen de Boer, Pietro L.<br />

Poliani, Michael N. Antoniou, Anna Villa, Chantal Lagresle-Peyrou,<br />

Marina Cavazzana-Calvo, Fang Zhang, Adrian J. Thrasher, Gerard<br />

Wagemaker.<br />

662<br />

Stem <strong>Cell</strong> and T-<strong>Cell</strong> <strong>Gene</strong> <strong>Therapy</strong> Using SIN-<br />

Lentiviral Vector in Type 3 Familial Hematophagocytic<br />

Lymphohistocytosis: A Comparative Approach<br />

Julie Rivière, Tayebeh Soheili, Els Verhoeyen, Anne Galy, <strong>Gene</strong>viève<br />

De Saint Basile, Marina Cavazzana-Calvo.<br />

663<br />

High Expression Bioengineered Factor VIII Enables<br />

AAV-Based <strong>Gene</strong> <strong>Therapy</strong> <strong>of</strong> Hemophilia A<br />

H. Trent Spencer, Harrison C. Brown, Jordan E. Shields, J. Fraser<br />

Wright, Christopher B. Doering.<br />

664<br />

Identiication <strong>of</strong> Novel Combination <strong>of</strong> Elements in<br />

cHS4 with Optimal Insulator Activity and Improved<br />

Titers in g-Globin Carrying SIN Lentiviral Vectors<br />

Paritha Arumugam, Michael Wourms, Joseph Starnes, Catherine<br />

Fox, Xiaoming Li, Punam Malik.<br />

665<br />

Intraosseous Delivery <strong>of</strong> Lentiviral Vectors Expressing<br />

Factor VIII under the Control <strong>of</strong> the Platelet-Speciic<br />

Glycoprotein 1ba Promoter Leads to Long-Term<br />

Correction <strong>of</strong> Bleeding in Hemophilia A Mice<br />

Xuefeng Wang, Andy Chiang, Simon C. Shin, Liping Chen, Dao Pan,<br />

David J. Rawlings, Carol H. Miao.<br />

666<br />

Lentiviral Vectors Tailored for Liver-Directed <strong>Gene</strong><br />

<strong>Therapy</strong> Do Not Show Any Detectable Genotoxicity in<br />

Sensitive In Vivo Biosafety Assays<br />

Marco Ranzani, Alessio Cantore, Monica Volpin, Pierangela Gallina,<br />

Stefano Annuziato, Francesca Sanvito, Fabrizio Benedicenti,<br />

Cynthia Bartholomae, Lucia Sergi Sergi, Christ<strong>of</strong> von Kalle,<br />

Manfred Schmidt, Claudio Doglioni, Luigi Naldini, Eugenio<br />

Montini.<br />

667<br />

Successful Liver <strong>Gene</strong> <strong>Therapy</strong> <strong>of</strong> Hemophilia B<br />

Dogs Using Lentiviral Vectors and Hyperfunctional<br />

Transgene<br />

Alessio Cantore, Patrizia Della Valle, Sara Bartolaccini, Lucia Sergi<br />

Sergi, Thierry VandenDriessche, Marinee Chuah, Dwight Bellinger,<br />

Armando D’Angelo, Timothy Nichols, Luigi Naldini.<br />

136<br />

<strong>Final</strong> <strong>Program</strong> SALT LAKE CITY, UTAH May 15–18, 2013

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