Final Program - American Society of Gene & Cell Therapy

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Program Schedule, Wednesday, May 15, 2013 Manfred Schmidt, PhD Clonality and Biosafety Aspects of Illegitimate Integration Integrating retroviral vectors have been used successfully in clinical applications. With the occurrence of integration associated severe side effects, enhanced efforts have been set for the clinical translation of integrase deicient viral vectors to guarantee improved biosafety. In this presentation, the focus is set on studies performed for assessing frequency, proile and mechanisms of (illegitimate) integration. Scott H. Robbins, PhD Development of an ID-LV as a Gene Delivery Platform for Immunotherapy Applications One of the most fundamental challenges for the design of next generation vaccines is the generation of antigen-speciic CD8 T cell responses. The direct administration of lentivector-based vaccines genetically encoding antigen is proving to be an effective approach to elicit CD8 T cell responses in pre-clinical animal models. The ability to alter the tropism of lentiviral vectors via pseudotyping and other mechanisms makes them attractive as a platform technology on which to base product candidates for clinical applications such as antigen-directed immunotherapy and vaccines. Examples of the functionality of integration-competent and -deicient lentiviral vectors as antigen delivery vehicles in pre-clinical settings will be provided as well as an example of the design of a dendritic cell-directed integration-deicient lentiviral vector that is currently under development as an antigen-directed cancer immunotherapy (a “cancer vaccine”). Wednesday, May 15, 2013 Oral Abstract Session 130 3:15 pm - 5:15 pm ROOM: BALLROOM A AAV Vector Development & Application CO-CHAIRS: Mavis Agbandje-McKenna, PhD and Hiroyuki Nakai, MD, PhD (Abstracts 1 through 8; see page 87) Oral Abstract Session 131 3:15 pm - 5:15 pm ROOM: BALLROOM B Cancer - Immunotherapy I CO-CHAIRS: Malcolm K. Brenner, MD, PhD and John J. Nemunaitis, MD (Abstracts 9 through 16; see pages 87-88) Oral Abstract Session 132 3:15 pm - 5:15 pm ROOM: 150 DEFG Cancer - Oncolytic Viruses CO-CHAIRS: David Kirn, MD and Stephen J. Russell, MD, PhD (Abstracts 17 through 24; see page 88) Oral Abstract Session 133 3:15 pm - 5:15 pm ROOM: BALLROOM C Advancing the Science of Gene Therapy for Hematologic Diseases CO-CHAIRS: Arnab Ghosh, MD, PhD and Donald B. Kohn, MD (Abstracts 25 through 32; see pages 88-89) Final Program SALT LAKE CITY, UTAH May 15–18, 2013 43
Program Schedule, Wednesday, May 15, 2013 Wednesday, May 15, 2013 Oral Abstract Session 134 3:15 pm - 5:15 pm ROOM: BALLROOM D Neurological Disorders: Monogeneic Disorders CO-CHAIRS: Raymond T. Bartus, PhD and Nicholas Boulis, MD (Abstracts 33 through 40; see page 89) Oral Abstract Session 135 3:15 pm - 4:15 pm ROOM: 151 ABCG Chemical and Molecular Conjugates CO-CHAIRS: Young Jik Kwon, PhD and Assem Ziady, PhD (Abstracts 41 through 44; see page 90) Oral Abstract Session 136 3:15 pm - 4:15 pm ROOM: 150 ABC Infectious Diseases and Vaccines CO-CHAIRS: Renata Stripecke, PhD and Grant D. Trobridge, PhD (Abstracts 45 through 48; see page 90) Oral Abstract Session 137 4:20 pm - 5:20 pm ROOM: 151 ABCG Cell Processing and Vector Production CO-CHAIRS: Adrian P. Gee, PhD and Isabelle Riviere, PhD (Abstracts 49 through 52; see page 90) Oral Abstract Session 138 4:20 pm - 5:20 pm ROOM: 150 ABC Sensory (Ophthalmic & Auditory) Gene & Cell Therapy CO-CHAIRS: Alberto Auricchio, MD and Tonia S. Rex, PhD (Abstracts 53 through 56; see page 91) Exhibit Hall Welcome Reception 5:15 pm - 7:15 pm ROOM: EXHIBIT HALL C/D 44 Final Program SALT LAKE CITY, UTAH May 15–18, 2013
Page 2 and 3: ASGCT Officers and Board of Directo
Page 4 and 5: Annual Meeting Exhibitors - as of A
Page 6 and 7: Annual Meeting Supporters Patron Le
Page 8 and 9: Committee Rosters Advisory Council
Page 10 and 11: Committee Rosters Host Committee Ch
Page 12 and 13: Committee Rosters Program Committee
Page 14 and 15: Abstract Reviewers Cancer - Immunot
Page 16 and 17: Outstanding New Investigator Awards
Page 18 and 19: Faculty List Thomas W. Chalberg, Jr
Page 20 and 21: Faculty List Ann M. Leen, PhD Baylo
Page 22 and 23: Faculty List Evan Y. Snyder, MD PhD
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Abstract Author Index Aartsma-Rus,
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Abstract Author Index Bartel, Ronnd
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Abstract Author Index Yanovich, Sau
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Final Program - American Society of Gene & Cell Therapy

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