Final Program - American Society of Gene & Cell Therapy

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Program Schedule, Saturday, May 18, 2013 ASGCT Business Meeting 7:30 am - 8:00 am ROOM: 150 ABC Plenary Session 400 8:00 am - 10:00 am ROOM: BALLROOM E-J Outstanding New Investigator Symposium CHAIR SPEAKERS Katherine P. Ponder, MD Aravind Asokan, PhD A Sweet Side to AAV Biology Adeno-associated viruses (AAV) exploit a spectrum of glycans for cell surface attachment and transduction. Understanding the structural basis and functional implications of such virus-host interactions can guide development of recombinant AAV vectors for clinical gene therapy applications. This talk will highlight our contributions towards discovery of AAV receptors, structural determinants of AAV tissue tropism and new strategies to re-engineer AAV-glycan interactions. Paloma H. Giangrande, PhD Targeted-Image Guided RNA (TIGR) Therapies The successful application of RNAi therapeutics to humans awaits the development of robust delivery technologies. Cell conjugation of siRNAs to cell-speciic ligands provides a viable solution to this problem. Synthetic RNA ligands (aptamers) represent an emerging class of pharmaceuticals with great potential for targeted therapeutic/diagnostic applications. Here, we describe advancements in aptamer technology for enabling the development of effective image-guided RNA therapies. Saturday, May 18, 2013 Final Program SALT LAKE CITY, UTAH May 15–18, 2013 69
Program Schedule, Saturday, May 18, 2013 Michael A. Lalamme, MD, PhD Cardiac Repair with Human Pluripotent Stem Cells Human pluripotent stem cells have a number of potential advantages for use in myocardial infarct repair, including tremendous capacity for expansion in the undifferentiated state and unambiguous cardiac potential. Our group irst reported what are now widely applied methods to eficiently guide the differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) into cardiomyocytes, as well as their further differentiation to speciic cardiac subtypes (e.g. pacemaker or ventricular myocytes). In early proof-of-concept studies using a rat infarct model, we showed that the transplantation of hESCderived cardiomyocytes results in partial remuscularization of the infarct scar and improved contractile function. More recently, we have used a guinea pig infarct model to show that hESC-derived cardiomyocyte grafts can integrate electrically and contract synchronously with host muscle; and that these grafts exert an intriguing arrhythmia-suppressive effect. Our ongoing efforts are focused on promoting the structural and functional maturation of hESC-derived cardiomyocytes, as well as their electromechanical integration in vivo. Ann M. Leen, PhD T cell Therapy for Viruses and Cancer Severe and fatal viral infections remain common after hematopoietic stem cell transplantation. Adoptive transfer of in vitro expanded cytotoxic T lymphocytes speciic for EBV, CMV and Adv antigens can treat infections that are impervious to conventional therapies. However, the time taken to prepare patient-speciic products, the limited breadth of viral speciicities that can be accommodated in a single line, and the lack of virus-speciic T-cells in cord blood and seronegative donors restricts application. In this presentation I will summarize our preclinical efforts to address these limitations and will present our clinical trial results using these products. Oral Abstract Session 410 10:15 am - 12:15 pm ROOM: 150 DEFG Late Breaking Abstracts CO-CHAIRS: TO BE DETERMINED (Abstracts 725 through 732; see page 124) Saturday, May 18, 2013 Oral Abstract Session 411 10:15 am - 12:15 pm ROOM: 150 ABC Adenovirus and Other DNA Virus Vectors CO-CHAIRS: Prem Seth, PhD and Miguel Sena-Esteves, PhD (Abstracts 477 through 484; see pages 124-125) 70 Final Program SALT LAKE CITY, UTAH May 15–18, 2013
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ASGCT Officers and Board of Directo
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Annual Meeting Exhibitors - as of A
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Annual Meeting Supporters Patron Le
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Committee Rosters Advisory Council
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Committee Rosters Host Committee Ch
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Committee Rosters Program Committee
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Abstract Reviewers Cancer - Immunot
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Outstanding New Investigator Awards
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Faculty List Thomas W. Chalberg, Jr
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Abstract Directory, Friday, May 17,
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Abstract Directory, Saturday, May 1
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Abstract Author Index Aartsma-Rus,
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Abstract Author Index Bartel, Ronnd
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Abstract Author Index Chicoine, Lou
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Abstract Author Index Daukandt, Mar
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Abstract Author Index Eleftheriadou
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Abstract Author Index Furth, Mark E
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Abstract Author Index Ling, Changqu
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Abstract Author Index Martin, Dougl
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Abstract Author Index Morishita, Na
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Abstract Author Index Okamoto, Sach
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Abstract Author Index Potter, Phil
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Abstract Author Index Ruggiero, Eli
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Abstract Author Index Shirakawa, To
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Abstract Author Index Swanson, Magd
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Abstract Author Index Ugai, Hideyo.
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Abstract Author Index Watts, Korash
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Abstract Author Index Yanovich, Sau
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Final Program - American Society of Gene & Cell Therapy

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