E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
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<strong>TRIM72</strong> blocks Akt activation in IGF signaling.<br />
Ad-EV<br />
0<br />
10<br />
30<br />
60<br />
120<br />
Ad-<strong>TRIM72</strong><br />
0<br />
10<br />
30<br />
60<br />
120<br />
Si-Con<br />
0<br />
10<br />
30<br />
60<br />
120<br />
Si-<strong>TRIM72</strong><br />
0<br />
10<br />
30<br />
60<br />
120<br />
mins after<br />
IGF activation<br />
<strong>TRIM72</strong><br />
p-Akt<br />
IGF<br />
Akt<br />
IGFR<br />
p-MAPK<br />
<strong>IRS</strong>-1<br />
MAPK<br />
PI-3-K<br />
Myoblast<br />
Myotube<br />
Actin<br />
p-AKT<br />
mTOR<br />
Hypertrophy<br />
Lee et al., CDD, 2010
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