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E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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Ring Finger domain of <strong>TRIM72</strong><br />

Consensus Sequence of Ring Finger Domain, Zn 2+ binding site<br />

CX 2 CX (9-39) CX (1-3) HX (2-3) C/HX 2 CX (4-48) CX 2 C<br />

<strong>TRIM72</strong> sequence<br />

MSAAPGLLHQELSCPLCLQLFDAPVTAECGHSFCRACLGRVAGEPAADGTVLC<br />

PCCQAPTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRALVCGV<br />

CASLGSHRGHRLLPAAEAHARLKTQLPQQKLQLQEACMRKEKSVAVLEHQLVV<br />

EETVRQFRGAVGEQLGKMRVFLAALEGSLDCEAERVRGEAGVALRRELGSLNS<br />

YLEQLRQMEKVLEEVADKPQTEFLMKYCLVTSRLQKILAESPPPARLDIQLPIISD<br />

DFKFQVWRKMFRALMPALEELTFDPSSAHPSLVVSSSGRRVECSEQKAPPAGED<br />

PRQFDKAVAVVAHQQLSEGEHYWEVDVGDKPRWALGVIAAEAPRRGRLHAVPS<br />

QGLWLLGLREGKILEAHVEAKEPRALRSPERRPTRIGLYLSFGDGVLSFYDASD<br />

ADALVPLFAFHERLPRPVYPFFDVCWHDKGKNAQPLLLVGPEGAEA<br />

C 14 C 17 C 29 H 31 C 34 C 37 C 53 C 56<br />

<strong>TRIM72</strong> C14A mutant <br />

<strong>TRIM72</strong> ∆RING mutant <br />

Zn 2+ Zn 2+

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