E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
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RING domain of <strong>TRIM72</strong> is required for the negative regulation<br />
of IGF signaling.<br />
0 2 5 0 2 5 0 2 5 0 2 5<br />
IGF-1 (min)<br />
<strong>TRIM72</strong><br />
pAkt<br />
Akt<br />
pErk1/2<br />
WCL<br />
Erk1/2<br />
<strong>IRS</strong>-1<br />
Actin<br />
IP:<strong>IRS</strong>-1, IB:pY<br />
IGF<br />
IGFR<br />
<strong>IRS</strong>-1<br />
PI-3-K<br />
<strong>TRIM72</strong><br />
IP:<strong>IRS</strong>-1, IB:<strong>IRS</strong>-1<br />
IP:<strong>IRS</strong>-1, IB:PI3K<br />
IP:IGFR, IB:<strong>IRS</strong>-1<br />
IP:IGFR, IB:pY<br />
IB:IGFR, IB:IGFR<br />
p-AKT<br />
mTOR<br />
Hypertrophy<br />
C2C12 myoblasts
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