E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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RING domain of TRIM72 is essential for the negative regulation of myogenesis. AD-LacZ AD-TRIM AD-C14A AD-∆R 20 µm Myogenic index (%) 100 80 60 40 20 ** * : < 0.01 ** : < 0.05 * ** TRIM72 MyHC Caveolin-3 Myogenin IRS-1 Actin C2C12 myotubes
RING domain of TRIM72 is required for the negative regulation of IGF signaling. 0 2 5 0 2 5 0 2 5 0 2 5 IGF-1 (min) TRIM72 pAkt Akt pErk1/2 WCL Erk1/2 IRS-1 Actin IP:IRS-1, IB:pY IGF IGFR IRS-1 PI-3-K TRIM72 IP:IRS-1, IB:IRS-1 IP:IRS-1, IB:PI3K IP:IGFR, IB:IRS-1 IP:IGFR, IB:pY IB:IGFR, IB:IGFR p-AKT mTOR Hypertrophy C2C12 myoblasts
Page 1 and 2: E3 ligase TRIM72 negatively regulat
Page 3 and 4: Insulin action through lipid rafts
Page 5 and 6: Functional proteomics of lipid raft
Page 7 and 8: C2C12 Myogenesis Myoblasts Myotubes
Page 9 and 10: TRIM72 gene analysis Myoblasts Myot
Page 11 and 12: TRIM72 is highly expressed during C
Page 13 and 14: What is a molecular target of TRIM7
Page 15 and 16: TRIM72 supresses IRS-1 phosphorylat
Page 17 and 18: TRIM72 negatively regulates myogene
Page 19: Ring Finger domain of TRIM72 Consen
Page 23 and 24: RING domain does not prevent bindin
Page 25 and 26: RING domain of TRIM72 is required f
Page 27 and 28: TRIM72 disruption enhances MyoD-dri
Page 29 and 30: E3 ligase activity Protein Ubiquit
Page 31 and 32: Molecular association of TRIM72 wit
Page 33 and 34: UbcH2 knockdown enhances myogenesis
Page 35 and 36: TRIM72 is highly expressed in soleu
Page 37 and 38: IRS-1 expression level is elevated
Page 39 and 40: E3 ligase TRIM72 negatively regulat
Page 41: Korea University Lab of Cell Signal

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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