E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
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UbcH2 knockdown enhances <strong>myogenesis</strong><br />
<strong>by</strong> inhibiting <strong>IRS</strong>-1 ubiquitination.<br />
Si-control<br />
Si-UbcH2<br />
+ - + -<br />
- + - +<br />
Si-control<br />
Si-UbcH2<br />
Myogenic index (%)<br />
60<br />
50<br />
40<br />
30<br />
20<br />
10<br />
*<br />
UbcH2<br />
MyHC<br />
Cav-3<br />
Mgn<br />
<strong>IRS</strong>-1<br />
UbcH2<br />
<strong>IRS</strong>-1<br />
WCL<br />
Ubiquitin<br />
<strong>IRS</strong>-1<br />
IP:<strong>IRS</strong>-1<br />
<strong>TRIM72</strong><br />
Actin<br />
C2C12 myotubes
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