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E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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Molecular association of <strong>TRIM72</strong> with <strong>IRS</strong>-1<br />

WCL<br />

Mock<br />

Ab<br />

0 5 30 0 5 30 mins after<br />

IGF activation<br />

<strong>TRIM72</strong><br />

IP: anti-<strong>IRS</strong>1<br />

<strong>IRS</strong>-1<br />

IGF<br />

IGFR<br />

IP: anti-CEMI<br />

<strong>IRS</strong>-1<br />

<strong>TRIM72</strong><br />

<strong>IRS</strong>-1<br />

PI-3-K<br />

<strong>TRIM72</strong><br />

p-AKT<br />

mTOR<br />

Hypertrophy<br />

Lee et al., CDD, 2010

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