E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
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Molecular association of <strong>TRIM72</strong> with <strong>IRS</strong>-1<br />
WCL<br />
Mock<br />
Ab<br />
0 5 30 0 5 30 mins after<br />
IGF activation<br />
<strong>TRIM72</strong><br />
IP: anti-<strong>IRS</strong>1<br />
<strong>IRS</strong>-1<br />
IGF<br />
IGFR<br />
IP: anti-CEMI<br />
<strong>IRS</strong>-1<br />
<strong>TRIM72</strong><br />
<strong>IRS</strong>-1<br />
PI-3-K<br />
<strong>TRIM72</strong><br />
p-AKT<br />
mTOR<br />
Hypertrophy<br />
Lee et al., CDD, 2010