E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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RING domain-lacking TRIM72 mutants work as dominant negative forms of endogenous TRIM72. - + - + - + - - + + - + - - - - + + Myc-TRIM Flag-TRIM Flag-C14A - + - + - - + + Myc-TRIM Flag-∆R IP: Myc, IB: Myc IP: Myc, IB: Myc IP: Myc, IB: Flag IP: Myc, IB: Flag IP: Flag, IB: Flag IP: Flag, IB: Flag IP: Flag, IB: Myc IP: Flag, IB: Myc IB: Myc (WCL) IB: Myc (WCL) IB: Flag (WCL) IB: Flag (WCL) TRIM72 oligomerization HEK 293 cells
RING domain does not prevent binding of TRIM72 to IRS-1 Differentiation days 0 1 2 3 7 A IRS-1 mRNA Actin mRNA + + + + Flag-IRS-1 TRIM72 Myogenin MyHC Cav-3 IP:Flag, IB:Flag IP:Flag, IB:HA IP:HA, IB:Flag IP:HA, IB:HA IRS-1 IB:Flag (WCL) Actin IB:HA (WCL) C2C12 cells HEK 293 cells
Page 1 and 2: E3 ligase TRIM72 negatively regulat
Page 3 and 4: Insulin action through lipid rafts
Page 5 and 6: Functional proteomics of lipid raft
Page 7 and 8: C2C12 Myogenesis Myoblasts Myotubes
Page 9 and 10: TRIM72 gene analysis Myoblasts Myot
Page 11 and 12: TRIM72 is highly expressed during C
Page 13 and 14: What is a molecular target of TRIM7
Page 15 and 16: TRIM72 supresses IRS-1 phosphorylat
Page 17 and 18: TRIM72 negatively regulates myogene
Page 19 and 20: Ring Finger domain of TRIM72 Consen
Page 21: RING domain of TRIM72 is required f
Page 25 and 26: RING domain of TRIM72 is required f
Page 27 and 28: TRIM72 disruption enhances MyoD-dri
Page 29 and 30: E3 ligase activity Protein Ubiquit
Page 31 and 32: Molecular association of TRIM72 wit
Page 33 and 34: UbcH2 knockdown enhances myogenesis
Page 35 and 36: TRIM72 is highly expressed in soleu
Page 37 and 38: IRS-1 expression level is elevated
Page 39 and 40: E3 ligase TRIM72 negatively regulat
Page 41: Korea University Lab of Cell Signal

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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