E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
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<strong>TRIM72</strong> supresses <strong>IRS</strong>-1 phosphorylation <strong>by</strong> IGF-1.<br />
0 2 10<br />
0 2 10<br />
mins after<br />
IGF activation<br />
Ad-EV<br />
Ad-TRIM<br />
Ad-EV<br />
Ad-TRIM<br />
Ad-EV<br />
Ad-TRIM<br />
Si-Con<br />
Si-TRIM<br />
Si-Con<br />
Si-TRIM<br />
Si-Con<br />
Si-TRIM<br />
c<br />
<strong>TRIM72</strong><br />
pAkt<br />
Akt<br />
IP, IGFR; IB, pTyr<br />
IP: <strong>IRS</strong>-1; IB, pTyr<br />
IGF<br />
IGFR<br />
<strong>IRS</strong>-1<br />
IP: <strong>IRS</strong>-1; IB, IGFR<br />
PI-3-K<br />
IP: <strong>IRS</strong>-1; IB, PI-3K<br />
p-AKT<br />
Myotube<br />
Myoblast<br />
IP: IGFR; IB, IGFR<br />
IP: <strong>IRS</strong>-1; IB, <strong>IRS</strong>-1<br />
mTOR<br />
Hypertrophy<br />
Lee et al., CDD, 2010
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