E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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RING domain of TRIM72 is required for IRS-1 ubiquitination. -MG132 +MG132 + - + - - + - + si-Control si-TRIM72 TRIM72 IRS-1 TRIM72 IRS-1 IP: α-IRS-1 IB: α-Ub IP: α-IRS-1 IB: α-Ub C2C12 Myoblasts IP: α-IRS-1 IB: α-IRS-1 IP: α-IRS-1 IB: α-IRS-1 C2C12 Myotubes
TRIM72 disruption enhances MyoD-driven myogenesis in MEFs. WT KO Differentiation days 0 1 2 3 4 TRIM72 MyoD Myogenin Caveolin-3 MyHC IRS-1 Actin Nuclei No. 5 4 3 2 1 WT KO TRIM72 MyoD Caveolin-3 Myogenin MyHC 0 WT KO IRS-1 Actin MyoD-driven myotubes from TRIM72 +/+ and -/- MEFs
Page 1 and 2: E3 ligase TRIM72 negatively regulat
Page 3 and 4: Insulin action through lipid rafts
Page 5 and 6: Functional proteomics of lipid raft
Page 7 and 8: C2C12 Myogenesis Myoblasts Myotubes
Page 9 and 10: TRIM72 gene analysis Myoblasts Myot
Page 11 and 12: TRIM72 is highly expressed during C
Page 13 and 14: What is a molecular target of TRIM7
Page 15 and 16: TRIM72 supresses IRS-1 phosphorylat
Page 17 and 18: TRIM72 negatively regulates myogene
Page 19 and 20: Ring Finger domain of TRIM72 Consen
Page 21 and 22: RING domain of TRIM72 is required f
Page 23 and 24: RING domain does not prevent bindin
Page 25: RING domain of TRIM72 is required f
Page 29 and 30: E3 ligase activity Protein Ubiquit
Page 31 and 32: Molecular association of TRIM72 wit
Page 33 and 34: UbcH2 knockdown enhances myogenesis
Page 35 and 36: TRIM72 is highly expressed in soleu
Page 37 and 38: IRS-1 expression level is elevated
Page 39 and 40: E3 ligase TRIM72 negatively regulat
Page 41: Korea University Lab of Cell Signal

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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