23.01.2015 Views

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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<strong>TRIM72</strong> disruption enhances MyoD-driven <strong>myogenesis</strong> in MEFs.<br />

WT<br />

KO<br />

Differentiation days<br />

0 1 2 3 4<br />

<strong>TRIM72</strong><br />

MyoD<br />

Myogenin<br />

Caveolin-3<br />

MyHC<br />

<strong>IRS</strong>-1<br />

Actin<br />

Nuclei No.<br />

5<br />

4<br />

3<br />

2<br />

1<br />

WT<br />

KO<br />

<strong>TRIM72</strong><br />

MyoD<br />

Caveolin-3<br />

Myogenin<br />

MyHC<br />

0<br />

WT<br />

KO<br />

<strong>IRS</strong>-1<br />

Actin<br />

MyoD-driven myotubes from <strong>TRIM72</strong> +/+ and -/- MEFs

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