E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...
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<strong>TRIM72</strong> disruption enhances MyoD-driven <strong>myogenesis</strong> in MEFs.<br />
WT<br />
KO<br />
Differentiation days<br />
0 1 2 3 4<br />
<strong>TRIM72</strong><br />
MyoD<br />
Myogenin<br />
Caveolin-3<br />
MyHC<br />
<strong>IRS</strong>-1<br />
Actin<br />
Nuclei No.<br />
5<br />
4<br />
3<br />
2<br />
1<br />
WT<br />
KO<br />
<strong>TRIM72</strong><br />
MyoD<br />
Caveolin-3<br />
Myogenin<br />
MyHC<br />
0<br />
WT<br />
KO<br />
<strong>IRS</strong>-1<br />
Actin<br />
MyoD-driven myotubes from <strong>TRIM72</strong> +/+ and -/- MEFs