E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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Molecular association of TRIM72 with UbcH2 - + - + Flag-UbcH2 - - + + Myc-WT Flag Myc Myc Flag Flag Myc WCL IP:IMyc IP:IFlag UbcH2 TRIM72 TRIM72 UbcH2 IP: TRIM72 IP: UbcH2 Exogenous IP in 293 cells Endogenous IP in C2C12 myotubes
UbcH2 knockdown enhances myogenesis by inhibiting IRS-1 ubiquitination. Si-control Si-UbcH2 + - + - - + - + Si-control Si-UbcH2 Myogenic index (%) 60 50 40 30 20 10 * UbcH2 MyHC Cav-3 Mgn IRS-1 UbcH2 IRS-1 WCL Ubiquitin IRS-1 IP:IRS-1 TRIM72 Actin C2C12 myotubes
Page 1 and 2: E3 ligase TRIM72 negatively regulat
Page 3 and 4: Insulin action through lipid rafts
Page 5 and 6: Functional proteomics of lipid raft
Page 7 and 8: C2C12 Myogenesis Myoblasts Myotubes
Page 9 and 10: TRIM72 gene analysis Myoblasts Myot
Page 11 and 12: TRIM72 is highly expressed during C
Page 13 and 14: What is a molecular target of TRIM7
Page 15 and 16: TRIM72 supresses IRS-1 phosphorylat
Page 17 and 18: TRIM72 negatively regulates myogene
Page 19 and 20: Ring Finger domain of TRIM72 Consen
Page 21 and 22: RING domain of TRIM72 is required f
Page 23 and 24: RING domain does not prevent bindin
Page 25 and 26: RING domain of TRIM72 is required f
Page 27 and 28: TRIM72 disruption enhances MyoD-dri
Page 29 and 30: E3 ligase activity Protein Ubiquit
Page 31: Molecular association of TRIM72 wit
Page 35 and 36: TRIM72 is highly expressed in soleu
Page 37 and 38: IRS-1 expression level is elevated
Page 39 and 40: E3 ligase TRIM72 negatively regulat
Page 41: Korea University Lab of Cell Signal

E3 ligase TRIM72 negatively regulates myogenesis by IRS-1 ...

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