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CPG for Eating Disorders

CPG for Eating Disorders

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Annex 1. Levels of Evidence and Grades ofRecommendationSIGN Levels of Evidence and Grades of RecommendationLevels of Evidence1++ High quality meta-analysis, systematic reviews of clinical trials or high-quality clinicaltrials with low risk of bias.1+ Well conducted meta-analysis, systematic reviews of clinical trials, or well conductedclinical trials with low risk of bias.1- Meta-analysis, systematic reviews of clinical trials, or clinical trials with high risk of bias.2++ High quality systematic reviews of cohort or case-control studiesCohort or case-control studies with very low risk of bias and high probability ofestablishing a causal relationship.2+ Well conducted cohort or case-control studies with low risk of bias and moderateprobability of establishing a causal relationship.2- Cohort or case-control studies with high risk of bias and significant risk of non-causalrelationship.3 Non-analytic studies such as case reports, case series or descriptive studies.4 Expert opinion.Grades of RecommendationABAt least one meta-analysis, systematic review or clinical trial classified as 1++ anddirectly applicable to the guide’s target population, or a body of evidence composed ofstudies classified as 1+ with high consistency amongst them.Body of evidence composed of studies classified 2++, directly applicable to the guide’starget population and that have been shown to have high consistency amongst them, orevidence extrapolated from studies classified as 1++ or 1+.212CLINICAL PRACTICE GUIDELINE FOR EATING DISORDERS

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