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CPG for Eating Disorders

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Summary of the Evidence<strong>CPG</strong> 30There is limited evidence to indicate that CBT is more acceptable than NC ininpatients with AN after weight restoration (1 RCT; N=33; Pike, 2003) 210 ..Recommendations(See recommendations 9.GM.1. to 9.GM.5.)9.2.2. Bulimia nervosa9.2.2.1. What is the efficacy of NC in patients with BN?The answer is based on the NICE <strong>CPG</strong> (2004) 30 . High-quality (1++) SRSE have also been takeninto account, one elaborated by the AHRQ of the US (2006) 31 and a more recently published oneby Shapiro, et al., . (2007) 211 , which include the same RCT. The updated search has not yieldednew evidence. Results are presented according to the variables studied in the RCT.Variables: reduction/ remission of binge-eating and purging episodesThere is limited evidence to suggest that CBT-BN is more effective than NC in reducingthe frequency of purging episodes by the end of treatment (SMD: -0.95; 95% CI: -1.70 to-0.20) and strong evidence <strong>for</strong> post-treatment follow-up (SMD: -1.34; 95% CI: -2.13 to -0.55) according to 1 RCT (N=31; Sundgot-Borgen, 2002) 212 .There is no evidence or insufficient evidence to determine that CBT-exposure withresponse prevention (ERP) <strong>for</strong> binge-eating episodes differs from NC (nutritionaltherapy) in the remission of binge-eating and purging (2 RCTs; N=90; Hsu, 2001 213 ;Jansen, 2002 214 ; RR: 0,82; 95% CI: 0.65 a 1.04) and in the frequency of binge-eating andpurging (1 RCT; N=49; Hsu, 2001 213 ; SMD: 0.43; 95% CI: -0.14 to 0.99) by the end oftreatment.RCT1++RCT1 ++Variables: depression and/or interpersonal and psychosocialfunctioning and/or general psychiatric symptomsThere is no evidence or insufficient evidence to determine that CBT-ERP differs from NC(nutritional therapy) in the scores obtained from the instrument used to assess depression (1RCT; N=49; Hsu, 2001 213 ; SMD: 0.15; 95% CI: -0.41 to 0.72). RCT 1 ++Summary of the EvidenceSRSE 311++If a cognitive component is added to NC (nutritional therapy) its effectivenessimproves (Hsu, 2001) 213 ..92CLINICAL PRACTICE GUIDELINE FOR EATING DISORDERS

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