Investigaciones Biomédicas “Alberto Sols”, CSIC, Universidade Autónoma de Madrid, Spain), M.M.Castro (<strong>CNC</strong>, Portugal).Disruption <strong>of</strong> hepatic glucose <strong>and</strong> lipid metabolism by immunosuppressive agents: implications <strong>for</strong>diagnosis <strong>and</strong> treatment <strong>of</strong> posttransplant diabetes. Virtudes Moreno Martinez (Inorganic ChemistryDepartment, University <strong>of</strong> Barcelona, Spain), Fern<strong>and</strong>o Avecilla Porto (Fundamental ChemistryDepartment, Universidade da Coruna, Spain), Duarte Mota de Freitas (Loyola University <strong>of</strong> Chicago,USA), Sebastian Cerdán (Laboratorio de RMN, Instituto de Investigaciones Biomédicas “Alberto Sols”,CSIC, Universidade Autónoma de Madrid, Spain), M.M. Castro (<strong>CNC</strong>, Portugal).Electrophysiology <strong>of</strong> purinergic P2X receptors. Pr<strong>of</strong>. Stanley Misler (Departments <strong>of</strong> Medicine <strong>and</strong> CellBiology/Physiology, Washington University Medical School, St Louis, MO, USA), Luis M. Rosário (<strong>CNC</strong>,Portugal).European Molecular Imaging Laboratory (EMIL) Network <strong>of</strong> Excellence (NoE); European Union FP6,involving a netwpork <strong>of</strong> about 56 European Laboratories working on Molecular Imaging, Carlos F. G. C.Geraldes (<strong>CNC</strong>, Portugal).In vivo NMR studies <strong>of</strong> hippocampal metabolism. Rolf Gruetter (EPFL, Switzerl<strong>and</strong>), John Jones (<strong>CNC</strong>,Portugal).Metabolic modeling <strong>of</strong> 13C <strong>and</strong> 2H‐tracer enrichments <strong>of</strong> glucose <strong>and</strong> other metabolites to hepaticintermediary metabolic fluxes. Matthew Merritt, Shawn Burgess (U.T. Southwestern Medical SchoolAdvanced Imaging <strong>Center</strong>, Dallas, TX), John Jones (<strong>CNC</strong>, Portugal).Metal‐based systems <strong>for</strong> Molecular Imaging applications. Involving about 45 European Laboratoriesworking on Molecular Imaging, Carlos F. G. C. Geraldes (<strong>CNC</strong>, Portugal).Noninvasive Analysis <strong>of</strong> hepatic lipid kinetics in rodent diabetes models by 1H MRS. Sebastian Cerdan(CSIC, Madrid), John Jones (<strong>CNC</strong>, Portugal).100Quantifying transaldolase exchange activity <strong>and</strong> its effects on gluconeogenic flux measurements using thedeuterated water tracer method. Robert Rizza, Rita Basu (Mayo Clinic, Minnesota, USA), John Jones(<strong>CNC</strong>, Portugal).SAXS study <strong>of</strong> aggregation behaviour <strong>of</strong> fluorene based conjugated polyelectrolytes. Dr. Matti Knaapila(MAX‐lab, Lund University, Sweden), L. Ramos (<strong>CNC</strong>, Portugal).Cell <strong>and</strong> Development BiologyAssessment <strong>of</strong> genetic heterogeneity in gliomas: impact on the clinical <strong>and</strong> biological behaviour <strong>of</strong> thedisease. Alberto Orfão (<strong>Center</strong> <strong>for</strong> Cancer Investigation, University <strong>of</strong> Salamanca, Spain), M.ª CelesteLopes (<strong>CNC</strong>, Portugal).CD38 <strong>and</strong> immune regulation. Fran Lund (Rochester University, USA), M.ª Celeste Lopes (<strong>CNC</strong>,Portugal).CD38 <strong>and</strong> immune responses against Mycobacterium tuberculosis. Andrea Cooper (Trudeau Institute,USA), M.ª Celeste Lopes (<strong>CNC</strong>, Portugal).Characterization <strong>of</strong> a new mucosatropic HPV type: HPV 108. Ethel de Villiers (DKFZ, Heidelberg,Germany), M.ª Celeste Lopes (<strong>CNC</strong>, Portugal).
Freeze‐dried primate sperm. Gabriel Sanchez‐Partida (Monash University, Australia), João RamalhoSantos (<strong>CNC</strong>, Portugal).Implications <strong>of</strong> Claspin mutations in DNA replication, cell cycle checkpoints <strong>and</strong> oncogenesis. RaimundoFreire (University Hospital <strong>of</strong> Canarias, Tenerife, Spain), M.ª Celeste Lopes (<strong>CNC</strong>, Portugal).Insulin resistance <strong>and</strong> fat cell biology. Dr. Jan Eriksson, University <strong>of</strong> Gothenburg, Sweden, EugéniaCarvalho, Maria Pereira (<strong>CNC</strong>, Portugal).Metabolic activity <strong>and</strong> viability <strong>of</strong> chondrocytes in cryopreserved human osteochondral allografts. AliMobasheri (School <strong>of</strong> Veterinary Science <strong>and</strong> Medicine, University <strong>of</strong> Nottingham, Engl<strong>and</strong>), M.ª CelesteLopes (<strong>CNC</strong>,Portugal).Mitochondria <strong>and</strong> embryonic stem cell pluripotency. Christopher Navara, Gerald Schatten (University <strong>of</strong>Pittsburgh, USA/University <strong>of</strong> Texas, San Antonio, USA), S<strong>and</strong>ra Varum (<strong>CNC</strong>, Portugal).Model <strong>of</strong> neuropeptide receptor KO mice in response to skin injury.Dr. Aris Veve, (Harvard MedicalSchool, USA), Eugénia Carvalho (<strong>CNC</strong>, Portugal).New methods to evaluate human sperm quality. Juan Vellez de la Calle (Clinique Pasteur, Brest, France),Vasco Almeida (Univ. Porto, Portugal), Helena Figueiredo (Hospital de Gaia, Portugal), Ana Paula Sousa,Renata Tavares (<strong>CNC</strong>, Portugal).Role <strong>and</strong> molecular mechanisms underlying CD36‐mediated phagocytosis <strong>of</strong> apoptotic cells: implications<strong>for</strong> atherosclerosis. Dr. Paul Verkade (Departments <strong>of</strong> Biochemistry <strong>and</strong> Physiology & Pharmacology,School <strong>of</strong> Medical Sciences, University <strong>of</strong> Bristol, Bristol, United Kingdom), Otília Vieira (<strong>CNC</strong>, Portugal).Role <strong>of</strong> RabGTPases (Rab8 <strong>and</strong> Rab35) on Phagocytosis <strong>and</strong> Phagosomal Maturation <strong>of</strong> IgG‐OpsonizedHeat‐killed <strong>and</strong> Virulent Mycobacterium tuberculosi. Pr<strong>of</strong>. Marino Zerial (Max‐Planck Institute <strong>for</strong>Molecular Cell Biology <strong>and</strong> Genetics. Dresden, Germany), Otília Vieira (<strong>CNC</strong>, Portugal).101Studies on the regulatory pathways involved in energy metabolism in the heart, particularly the integratedregulation <strong>of</strong> fatty acid oxidation <strong>and</strong> carbohydrate metabolism in both the normal heart <strong>and</strong> thereperfused ischemic heart. Dr. Gary Lopaschuk, (Dept. Pediatrics <strong>and</strong> Pharmacology, University <strong>of</strong>Alberta, Canada), Sara Goncalves, Eugénia Carvalho (<strong>CNC</strong>, Portugal).Study <strong>of</strong> the cytokine release pr<strong>of</strong>ile, by protein arrays, <strong>of</strong> dendritic cells. Carmen García‐Rodriguez(Institute <strong>of</strong> Biology <strong>and</strong> Molecular Genetic. CSIC‐University <strong>of</strong> Valladolid, Spain), M.ª Celeste Lopes(<strong>CNC</strong>,Portugal).Surfactants in the Prophylaxis <strong>of</strong> Sexually Transmitted Infections <strong>and</strong> in Oral Hygiene. Dr. Alfin Vaz(Pfizer Laboratories, Groton, USA), Otília Vieira (<strong>CNC</strong>, Portugal).Testicular organization <strong>and</strong> xenotransplanting <strong>of</strong> testicular tissue in cats. Stefan Schlatt (University <strong>of</strong>Pittsburgh, USA/ University <strong>of</strong> Muenster, Germany), Paula Mota (<strong>CNC</strong>, Portugal).The role <strong>of</strong> PTP1b in inflammation. Dr. Janice Zabolotny (Harvard Medical School, USA), EugéniaCarvalho (<strong>CNC</strong>, Portugal).
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General ObjectivesThe CNC major mis
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OrganizationThe Center for Neurosci
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