Annual Report of Activities CNC 2008 - Center for Neuroscience and ...

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Biomedical NMRDefining the effects of transaldolase exchange activity on tracer assays of hepatic gluconeogenesis andindirect pathway fluxes.Automated Bayesian analysis for 2H NMR spectra of urinary glucuronide.Correlating tracer measurements of hepatic glycogenolytic fluxes in Type 1 diabetes patients with in vivomeasurements by localized 13C MRS.Preservation of metabolic fluxes in hearts using cardioplegic solutions. Characterization of mitochondrialbioenergetics and immunological profiles in ischemia and ischemia/reperfusion.Evaluation of metabolic fluxes in hippocampus and protection of cognitive performance by caffeine.Correlation of energy metabolism with adenosine receptor‐mediated neuroprotection.Future PlansThe Cell Biophysics group will investigate the role played by voltage‐sensitive Ca2+ (Cav1) channels asearly sensors of glucose metabolism in pancreatic β‐cells, acting in concert with KATP channels to supportbursting electrical activity and pulsatile insulin release. The working model assumes that Cav1 channelsundergo slow and voltage‐independent inactivation, modulated by either glucose metabolites or productsarising from glucose metabolism. Further work will be carried out to assess whether Cav1 channels mightbe involved in β‐cell dysfunction, using an animal model of type 2 diabetes (Goto‐Kakizaki rats).The IB and MI group will develop new metal containing multimodal targeted MI diagnostic tools, eg. MRICAs, optimizing efficacy, safety and sensitivity of reporter groups, based on chelates or nanoparticles, andthe specificity of targeting vectors. Best agents will be studied with cell and animal models.66Study non‐covalent binding of Ln‐chelates to proteins using STD NMR and develop and study new Lnbinding tags rigidly attached to multidomain proteins for NMR structural and dynamic studies.Study binding of Li+ to cells using 7/6Li and MQ 23Na NMR techniques and effects of new V complexeson glucose uptake, metabolism and toxicity in adipocytes and a rat model of Type 2 diabetes, usingbiochemical and NMR tracer techniques. Study toxicological effects of Cr(VI) compounds and conjugatedpolymers as biosensors.The Biomedical NMR group will quantify de novo lipogenesis (DNL) fluxes by D2O and 2H NMR anddetermine the contribution of DNL and [U‐13C]enriched dietary triglycerides to hepatic lipid levels innormal and pathophysiological states.; further develop LC‐MS based assays of 2H and 13C‐enrichment ofglucose and glucuronide and apply these to animal and human glucose clamp studies; metaboliccharacterization of neurodegenerative disorders, correlating cognitive impairment with alterations inintermediary metabolism.
Inorganic Biochemistry and Molecular Imaging GroupCarlos G. Geraldes(PhD – Head of group)Mª Margarida Catalão Castro (PhD)Mª Carmen Alpoim (PhD)Mª Luisa D. Ramos (PhD)Licinia J. Simões(Post‐Doctoral Fellow)Giovannia Araujo de Lima Pereira (Post‐Doctoral Fellow)Carlos RodriguesSara FigueiredoMaria João Rodrigues PereiraAndré MartinsJoão André DuarteJoão TeixeiraFilipe Coreta GomesInes Ribeiro ViolanteMarta Daniela P. Caetano(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(Undergraduate Student)(Grant Technician)67Intermediary Metabolism GroupJohn Griffith Jones(Ph.D. – Head of group)Rui A. Carvalho(PhD)Mª Madalena Caldeira Santos (PhD)Ivana JarakTiago AlvesAna Francisca L. Silva SoaresSara GonçalvesIvan ViegasPedro CoxitoMarco AlvesCristina BarosaIlídio MartinsPaulo Gameiro GuerreiroDaniela Pinheiro(PhD)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(Grant Technician)
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General ObjectivesThe CNC major mis
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OrganizationThe Center for Neurosci
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Microbiology | Milton CostaMicrobio
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Page 18 and 19: Neuroprotection and Neurogenesis in
Page 20 and 21: Retinal Dysfunction and Neurogenesi
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Page 24 and 25: Neuronal Cell Death and Neuroprotec
Page 26 and 27: Molecular Mechanisms of Disease | H
Page 28 and 29: PublicationsAgasse F, Bernardino L,
Page 30 and 31: Santiago AR, Carvalho, CM, Carvalho
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Page 34 and 35: Vectors and Gene Therapy GroupM. Co
Page 36 and 37: Molecular Systems Biology | Head: A
Page 38 and 39: Vectors and Gene Therapy | Head: Ma
Page 40 and 41: PublicationsAlves S, Nascimento‐F
Page 43 and 44: Area C | Cell and Molecular Toxicol
Page 45 and 46: Mitochondrial Toxicology and Pharma
Page 47: Pharmacometrics GroupAmílcar Falc
Page 50 and 51: Free Radicals and Antioxidants in B
Page 52 and 53: Pharmacometrics | Head: Amílcar Fa
Page 54 and 55: Correia S, Carvalho C, Santos MS, P
Page 57 and 58: Area D | MicrobiologyCoordinator |
Page 59: Microbiology of Extreme Environment
Page 62 and 63: Medical Mycology - Yeast Research |
Page 65: Area E | Biophysics and Biomedical
Page 69 and 70: Inorganic Biochemistry and Molecula
Page 71 and 72: Cell Biophysics |Head: Luís Martin
Page 73: Sobral AJFN, Justino LLG, Santos AC
Page 76 and 77: Future PlansThere is an enormous we
Page 78 and 79: Paula MotaSara M. Diniz Martins Lop
Page 80 and 81: Biology of Reproduction and Human F
Page 82 and 83: Insulin Resistance and Adipocyte |
Page 85 and 86: Biomedical Inter‐Institutional Re
Page 87 and 88: 3. Pediatric Research: metabolic di
Page 89 and 90: PublicationsSantos MJ, Cleto S, Men
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Page 98 and 99: Anticancer Effects of of Phytochemi
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Page 104 and 105: May 2008Member of the organizing co
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Page 108 and 109: Genome BiologyFebruary 25 ‐ 27Isa
Page 110 and 111: Seminars2008 Series | CNC Audithori
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Elisabete Ferreiro“Cross‐talk b
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Ana Isabel Vicente Rafael“Estudos
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Rosete Pais“Papilomavirus humano
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FLOW CYTOMETRY UNITHead of Unit: Is
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MASS SPECTROMETRY UNITHead of Unit:
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Amino Acid AnalysisOur laboratory r
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2. Areas of Expertise / Research /
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Multiple SclerosisAn extension of t
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2.2. Centre for Bioavailability Stu
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StaffCoordinatorTice Macedo, MD, Ph
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Compatible solutes from extremophil
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Proteases aspárticas secretadas em
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Mecanismos de plasticidade sinápti
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Clivagem dos transportadores vesicu
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ʺBIOINK ‐ Aprendizagem increment
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Henrique Faneca (Auxiliar Inv., CNC
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Liliana Bernardino 100Luis Miguel E
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João Teixeira 100João Teodoro 100
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Patricia Henriques Domingues 100Pat
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ADMINISTRATIVE STAFFTime % at CNCAr
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Sandra Isabel M. Cardoso (Auxiliar
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Molecular Biotechnology and HealthE
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Cell and Molecular ToxicologyLeonor
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MicrobiologyMilton Costa, PhD, Coor
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Paulo Gameiro Guerreiro 100Pedro Co
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Marta Isabel Rodrigues Baptista 100
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Url: http://www.cnbc.pt | Email: in
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