Annual Report of Activities CNC 2008 - Center for Neuroscience and ...

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“Nano‐transportadores de base lipídica para entrega direccionada de vectores virais e processo para a suaprodução”Ana Filipe, M. C. Pedroso de Lima, Mauro Giacca and Sérgio Simões. Request number:PCT/IB2008/054399.“Targeted drug delivery to human diseases and disorders “Moreira, J. N., Moura, V., Pedroso de Lima, M.C., Simões, S., US Patent Application: Serial n.º 12/153,649.“Human papilloma virus detection kit” Nobre, R., Pereira de Almeida L., Martins T., US ProvisionalPatent Application: Ref. PAT‐US 38267/08.“Stable and readily dissolved compositions of Candesartan cilexetil prepared with wetgranulation”Gabriel Silva, Sérgio Simões and Frank Gindulis.; 91881 EP (BE/BS).“Synthesis of Compounds Relating to Photodynamic Therapy of Cancer”. L. G. Arnaut, M. M. Pereira, S. J.Formosinho, S. Simões, G. Stochel and K. Urbanska. Universidade de Coimbra. UK Patent Application no.0819594.3, 24th of October, 2008.Organization of conferencesProgram Committee, International Conference on Molecular Systems Biology, Diliman (Philippines)Industry contract research“Design of a biomimetic injectable scaffold for the transplantation and differentiation of umbilical cordstem cells‐ InjectCord”. Funding: 70,000 euros. Source: Crioestaminal.“Antifungal nanocoatings”. Funding: 150,000 euros. Source: Biocant Ventures. BIOCANT VENTURES“Production of recombinant growth factors for cell culture”, Source: Criostaminal32“Production of a new milk coagulant based on cardosins”, Source: BIOCANT VENTURESʺNanomedicine and new therapeutic strategies: development of supramolecular strategies for therapy ofophthalmologic diseases”,Partnership with the industry Bluepharma. Source: CCRDC – Coordinatorcommittee for regional development of the Center.Future PlansThe research activity developed by the investigators of this line aims at: 1) understanding interactions ofliving organisms components from a molecular level to system level; 2) design strategies with the potentialto modulate these interactions. The work performed by the Molecular Systems Biology, the Structural andComputational Biology and by the Molecular Biotechnology groups is concerned with the first aimwhereas the work performed by the groups Vectors and Gene Therapy and Biomaterials and Stem Cell –based therapy is concerned with the second aim.In brief the future working plans of the groups concerned with the first aim are: to pursue with theanalysis of the design principles of metabolism and to proceed to experimental validation of modelspurposed; to carry on the search for clusters of genes associated with diseases; to characterize mechanismsof protein aggregation that lead to diseases; rational design and testing of lead compounds for inhibitionof amyloid formation; identification of the natural substrates of the recent unvealed proteases CDR 1(constitutive disease resistant protease) and RCS1 (promoter of cell survival protease); proceed with themolecular characterization of the pollen proteases that show high ability to cause airway damage. In whatit concern the second aim the future working plans are: development of the use of viral and non viraltechnological platforms to generate new models of CNS diseases; do develop new approachs fortransplantation of stem cells, in particular vascular progenitor cells; to develop new tools to image, non –invasively, transplanted stem cells; to develop antimicrobial coating for medical device surfaces.
Molecular Biotechnology GroupCarlos Faro(PhD – Head of group)Euclides PiresPaula Veríssimo PiresAna Sofia F. de AlmeidaRui CruzRaquel VinhasNair MonteiroMaria Inês Coelho(PhD)(PhD)(PhD Student)(MSc Student)(MSc Student)(Undergraduate Student)(Undergraduate Student)Molecular Systems Biology GroupArmindo J. Alves S. Salvador(PhD – Head of group)Bharathi PanduranganPedro Miguel Brás M. CoelhoInês Vasconcelos Miranda SantosPedro Manuel Batista BrancoPedro Alexandre MartinsFlávio Fortes R. Sousa(Post‐Doctoral Fellow)(PhD Student)(PhD Student)(PhD Student)(MSc Student)(MSc Student)33Structural and Computational BiologyRui M. M. Brito(PhD – Head of group)Elsa HenriquesDaniela Cipreste VazCândida S. Gonçalves da SilvaCarlos José Vieira SimõesCatarina Sofia H. JesusPedro Cruz(PhD)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(Grant Technician)
Page 7 and 8: General ObjectivesThe CNC major mis
Page 11 and 12: OrganizationThe Center for Neurosci
Page 13: Microbiology | Milton CostaMicrobio
Page 16 and 17: per year) will be proposed by the g
Page 18 and 19: Neuroprotection and Neurogenesis in
Page 20 and 21: Retinal Dysfunction and Neurogenesi
Page 22 and 23: Glutamatergic synapses | Head: Ana
Page 24 and 25: Neuronal Cell Death and Neuroprotec
Page 26 and 27: Molecular Mechanisms of Disease | H
Page 28 and 29: PublicationsAgasse F, Bernardino L,
Page 30 and 31: Santiago AR, Carvalho, CM, Carvalho
Page 34 and 35: Vectors and Gene Therapy GroupM. Co
Page 36 and 37: Molecular Systems Biology | Head: A
Page 38 and 39: Vectors and Gene Therapy | Head: Ma
Page 40 and 41: PublicationsAlves S, Nascimento‐F
Page 43 and 44: Area C | Cell and Molecular Toxicol
Page 45 and 46: Mitochondrial Toxicology and Pharma
Page 47: Pharmacometrics GroupAmílcar Falc
Page 50 and 51: Free Radicals and Antioxidants in B
Page 52 and 53: Pharmacometrics | Head: Amílcar Fa
Page 54 and 55: Correia S, Carvalho C, Santos MS, P
Page 57 and 58: Area D | MicrobiologyCoordinator |
Page 59: Microbiology of Extreme Environment
Page 62 and 63: Medical Mycology - Yeast Research |
Page 65 and 66: Area E | Biophysics and Biomedical
Page 67 and 68: Inorganic Biochemistry and Molecula
Page 69 and 70: Inorganic Biochemistry and Molecula
Page 71 and 72: Cell Biophysics |Head: Luís Martin
Page 73: Sobral AJFN, Justino LLG, Santos AC
Page 76 and 77: Future PlansThere is an enormous we
Page 78 and 79: Paula MotaSara M. Diniz Martins Lop
Page 80 and 81: Biology of Reproduction and Human F
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Insulin Resistance and Adipocyte |
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Biomedical Inter‐Institutional Re
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3. Pediatric Research: metabolic di
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PublicationsSantos MJ, Cleto S, Men
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7. Research in brain cancer: geneti
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Grafting SVZ neural stem cell cultu
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Structure‐function analysis of th
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Anticancer Effects of of Phytochemi
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Investigaciones Biomédicas “Albe
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Participation in the organization o
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May 2008Member of the organizing co
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Genome BiologyFebruary 25 ‐ 27Isa
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Seminars2008 Series | CNC Audithori
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13.6.2008Cells caught in the act: M
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5.12.2008Unexpected fate and functi
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Elisabete Ferreiro“Cross‐talk b
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Ana Isabel Vicente Rafael“Estudos
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Rosete Pais“Papilomavirus humano
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FLOW CYTOMETRY UNITHead of Unit: Is
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MASS SPECTROMETRY UNITHead of Unit:
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Amino Acid AnalysisOur laboratory r
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2. Areas of Expertise / Research /
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Multiple SclerosisAn extension of t
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2.2. Centre for Bioavailability Stu
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StaffCoordinatorTice Macedo, MD, Ph
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Compatible solutes from extremophil
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Proteases aspárticas secretadas em
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Mecanismos de plasticidade sinápti
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Clivagem dos transportadores vesicu
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ʺBIOINK ‐ Aprendizagem increment
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Henrique Faneca (Auxiliar Inv., CNC
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Liliana Bernardino 100Luis Miguel E
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João Teixeira 100João Teodoro 100
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Patricia Henriques Domingues 100Pat
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ADMINISTRATIVE STAFFTime % at CNCAr
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Sandra Isabel M. Cardoso (Auxiliar
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Molecular Biotechnology and HealthE
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Cell and Molecular ToxicologyLeonor
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MicrobiologyMilton Costa, PhD, Coor
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Paulo Gameiro Guerreiro 100Pedro Co
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Marta Isabel Rodrigues Baptista 100
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Url: http://www.cnbc.pt | Email: in
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