Santiago AR, Carvalho, CM, Carvalho AP, Ambrósio, AF (<strong>2008</strong>). Differential contribution <strong>of</strong> L‐, N‐, <strong>and</strong>P/Q‐type calcium channels to [Ca2+]i changes evoked by kainate in hippocampal neurons. Neurochem. Res.33: 1501‐1508.Santiago AR, Hughes JM, Kamphuis W, Schlingemann RO <strong>and</strong> Ambrósio AF (<strong>2008</strong>) Diabetes changesionotropic glutamate receptor subunit expression level in the human retina. Brain Res. 1198:153‐159.Santos AR, Duarte CB (<strong>2008</strong>) Validation <strong>of</strong> internal control genes <strong>for</strong> expression studies: effects <strong>of</strong> theneurotrophin BDNF on hippocampal neurons. J. Neurosci. Res. 86, 3684‐3692.Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA,Linden J, Tsien JZ, Chen JF (<strong>2008</strong>) A critical role <strong>of</strong> the adenosine A2A receptor in extrastriatal neurons inmodulating psychomotor activity as revealed by opposite phenotypes <strong>of</strong> striatum <strong>and</strong> <strong>for</strong>ebrain A2Areceptor knock‐outs. J. Neurosci. 28:2970‐5.Silva AM, Rodrigues RJ, Tomé AR, Cunha RA, Misler S, Rosário LM, Santos RM (<strong>2008</strong>)Electrophysiological <strong>and</strong> immunocytochemical evidence <strong>for</strong> P2X purinergic receptors in pancreatic betacells. Pancreas 36:279‐83.Silva BA, Malva JO <strong>and</strong> Dias ACP (<strong>2008</strong>) St. John’s worth (H. per<strong>for</strong>atum) extracts <strong>and</strong> isolated compoundsare effective antioxidants in several in vitro models <strong>of</strong> oxidative stress. Food Chem. 110: 611‐619.Silva B, Oliveira PJ, Dias ACP <strong>and</strong> Malva JO (<strong>2008</strong>) Quercetin, kaempferol <strong>and</strong> biapigenin fromHypericum per<strong>for</strong>atum are neuroprotective against excitotoxic insults. Neurotoxicity Res. 13: 265‐279.Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X (<strong>2008</strong>) Amyloid‐betaoverproduction causes abnormal mitochondrial dynamics via differential modulation <strong>of</strong> mitochondrialfission/fusion proteins. Proc. Natl. Acad. Sci. U.S.A. 105,19318‐19323.Xapelli S, Bernardino L, Ferreira R, Grade S, Silva AP, Salgado JR, Cavadas C, Grouzmann E, Poulsen FR,Jakobsen B, Oliveira CR, Zimmer J <strong>and</strong> Malva JO (<strong>2008</strong>) Interaction between neuropeptide Y (NPY) <strong>and</strong>brain‐derived neurotrophic factor in NPY‐mediated neuroprotection against excitotoxicity: a role <strong>for</strong>microglia. Eur. J. Neurosci. 27: 2089‐2102.Yu L, Shen HY, Coelho JE, Araújo IM, Huang QY, Day YJ, Rebola N, Canas PM, Rapp EK, Ferrara J, TaylorD, Müller CE, Linden J, Cunha RA, Chen JF (<strong>2008</strong>) Adenosine A2A receptor antagonists exert motor <strong>and</strong>neuroprotective effects by distinct cellular mechanisms. Ann. Neurol. 63:338‐46.30
Area B | Molecular Biotechnology <strong>and</strong> HealthCoordinator | Euclides PiresGeneral ObjectivesLiving organisms are built <strong>of</strong> interacting components whose correct function or dysfunction leadsrespectively to health or disease conditions. Underst<strong>and</strong>ing interactions, from the molecular level to thesystem level, is a tremendous task crucial to the design <strong>of</strong> strategies capable <strong>of</strong> correcting dysfunction.The Biotechnology <strong>and</strong> Health Line <strong>of</strong> <strong>CNC</strong> has been “shapped” steadly by hiring young scientists withthe competence to investigate interactions at different levels <strong>and</strong> apply this know ‐ how to a selected set <strong>of</strong>pathologies. At present this Line comprises five research groups whose general objectives are: 1) unvealclusters <strong>of</strong> genes associated with some diseases; 2) exploit design principles in metabolic networks; 3)investigate molecular interactions as well protein folding <strong>and</strong> unfolding using computationalmethodologies; 3) search, structural characterization <strong>and</strong> kinetics <strong>of</strong> proteases with biomedical orbiotechnological interest; 5) development <strong>of</strong> viral <strong>and</strong> non‐viral drug carriers; 6) development <strong>of</strong>biomaterials <strong>for</strong> stem cell‐based therapeutics; 7) development <strong>of</strong> a technological plat<strong>for</strong>m to generate newmodels <strong>of</strong> human CNS diseases.Main Achievements• A generic approach <strong>for</strong> characterizing <strong>and</strong> quantifying global tolerance <strong>of</strong> Biochemical systems wasproposed.• A computational tool <strong>for</strong> integrated visualization <strong>of</strong> protein interaction networks <strong>and</strong> RNA expressionwas devised.31• A prototype <strong>for</strong> a public open plat<strong>for</strong>m to share protein folding <strong>and</strong> unfolding was developed.• New data mining tools <strong>for</strong> analysis <strong>of</strong> multiple protein folding <strong>and</strong> unfolding simulations started to bedeveloped.• The most common <strong>and</strong> abundant allergenic pollens were shown to contain serine <strong>and</strong>/oraminopeptidase activity which is instrumental in degrading intercellular adhesion proteins.• A novel lipid – based nanosystem that has the potential to target the microenvironment <strong>of</strong> human breasttumor was developed.• A new approach <strong>for</strong> delivery <strong>of</strong> vascular growth factors into embryonic stem cells was established.• New nanomaterials <strong>for</strong> drug release <strong>and</strong> cell tracking were developed.Future ResearchPatents/prototypes“Human embryoid bodies containing nano‐ <strong>and</strong> micro‐particulate delivery vehicles” Ferreira, L., Kohane,D., Langer, R. Patent pending, <strong>2008</strong>.“A biodegradable <strong>and</strong> biocompatible Gecko‐inspired tissue adhesive”.Lino Ferreira, Alborz Mahdavi,Cathryn Sundback, David J. D. Carter, Chris Bettinger, Andreas Zumbuehl, Jeff Borenstein, JosephVacanti, Robert Langer, Jeffrey M. Karp. Patent pending, <strong>2008</strong>.
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Seminars2008 Series | CNC Audithori
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Elisabete Ferreiro“Cross‐talk b
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StaffCoordinatorTice Macedo, MD, Ph
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ʺBIOINK ‐ Aprendizagem increment
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Molecular Biotechnology and HealthE
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Url: http://www.cnbc.pt | Email: in
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