Structure‐function analysis <strong>of</strong> the NMDA receptor domains involved in synaptic delivery under basalconditions <strong>and</strong> during synaptic plasticity. Ann Marie Craig (Brain Research Centre, University <strong>of</strong> BritishColumbia, Vancouver, BC, Canada), Ana Luisa Carvalho (<strong>CNC</strong>, Portugal).The involvement <strong>of</strong> mitochondrial dysfunction <strong>and</strong> oxidative stress in Alzheimer disease. G. Perry (Univ.Texas at San Antonio, USA), Xiongwei Zhu (Case Western Reserve Univ., Clevel<strong>and</strong>, USA), Mark Smith(Case Western Reserve Univ., Clevel<strong>and</strong>, USA), Claudia Pereira (<strong>CNC</strong>, Portugal).Toxic pathways triggered by activation <strong>of</strong> Ca2+‐permeable AMPA receptors. Edward Barsoumian, MasakiIizuka (Nippon Boehringer Ingelheim Co., Ltd, Kawanishi Pharma Research Institute, Kawanishi, Japan),Carlos B. Duarte (<strong>CNC</strong>, Portugal).Use <strong>of</strong> caffeine to prevent cognitive decline in aging <strong>and</strong> in experimental models <strong>of</strong> Alzheimer’s disease:influence <strong>of</strong> gender <strong>and</strong> <strong>of</strong> trophic factors. Diogo O. Souza (Federal University <strong>of</strong> Rio Gr<strong>and</strong>e do Sul,Brazil), Rodrigo Cunha (<strong>CNC</strong>, Portugal).Molecular Biotechnology <strong>and</strong> HealthAAV vectors‐mediated gene therapy. Sebastian Kugler (Department <strong>of</strong> Neurology, Faculty <strong>of</strong> Medicine,S2‐Laboratory, University <strong>of</strong> Göttingen, University <strong>of</strong> Gottingen, Waldweg 33, 37073 Gottingen,Germany), Luís Pereira de Almeida (<strong>CNC</strong>, Portugal).Analysis <strong>of</strong> the structure <strong>of</strong> metabolic networks. George Stephanopoulos (M.I.T., U.S.A.),ArmindoSalvador (<strong>CNC</strong>, Portugal).Antimicrobial coatings. Robert Langer (Department <strong>of</strong> Chemical Engineering, Massachusetts Institute <strong>of</strong>Technology, MIT, EUA), Andreas Zumbuehl (Department <strong>of</strong> organic Chemistry, University <strong>of</strong> Geneva,Switzerl<strong>and</strong>), Cristiana Paulo, Lino Ferreira (<strong>CNC</strong>, Portugal).96Application <strong>of</strong> non‐viral suicide gene therapy approaches in animal models <strong>for</strong> cancer: molecular <strong>and</strong>cellular events associated with the antitumor response. Valérie Pierrefite‐Carle (Unity INSERM, Faculty <strong>of</strong>Medicine, Nice, France), M. Conceição Pedroso de Lima (<strong>CNC</strong>, Portugal).Cell internalization mechanisms <strong>of</strong> cell‐penetrating peptides. Abraham Loyter (Department <strong>of</strong> BiologicalChemistry, Institute <strong>of</strong> Life Sciences, Hebrew University <strong>of</strong> Jerusalem, Israel), M. Conceição Pedroso deLima (<strong>CNC</strong>, Portugal).Design principles <strong>of</strong> biochemical circuits, mathematical methods <strong>for</strong> systems analysis <strong>of</strong> biochemicalnetworks. Mchael Savageau (U.C. Davis, U.S.A.), Armindo Salvador (<strong>CNC</strong>, Portugal).Development <strong>of</strong> lipid‐based gene delivery systems <strong>for</strong> application in gene therapy. Nejat Duzgunes(University <strong>of</strong> the Pacific, San Francisco, USA), M. Conceição Pedroso de Lima (<strong>CNC</strong>, Portugal).Development <strong>of</strong> non‐viral vectors <strong>for</strong> siRNA delivery to the central nervous system. Ernst Wagner(Department <strong>of</strong> Pharmacy, University <strong>of</strong> Munich, Germany) M. Conceição Pedroso de Lima (<strong>CNC</strong>,Portugal).Development <strong>of</strong> three‐dimensional matrices <strong>for</strong> differentiation <strong>and</strong> transplantation <strong>of</strong> human stem cells <strong>for</strong>regenerative medicine. Robert Langer (Department <strong>of</strong> Chemical Engineering, Massachusetts Institute <strong>of</strong>Technology, MIT, EUA), Ali Khademhosseini (Harvard‐MIT Division <strong>of</strong> Health Science <strong>and</strong> Technology,USA), Helena Vazão, Lino Ferreira (<strong>CNC</strong>, Portugal).
Encapsulation <strong>of</strong> viral vectors into targeted nanolipid‐based carriers: evaluation <strong>of</strong> therapeutic activity inanimal models <strong>of</strong> ischemia. Mauro Giacca (Laboratory <strong>of</strong> Molecular Medicine, ICGEB ‐ InternationalCentre <strong>for</strong> Genetic Engineering <strong>and</strong> Biotechnology, Trieste, Italy), Sérgio Simões (<strong>CNC</strong>, Portugal).Energetic constraints on gene expression in S. cerevisiae, methods <strong>and</strong> s<strong>of</strong>tware <strong>for</strong> kinetic modeling,factors shaping proteins’ aminoacid usage. Rui Alves, Albert Sorribas, Ester Villaprinyó (University <strong>of</strong>Lleida, Spain), Armindo Salvador (<strong>CNC</strong>, Portugal).Gecko‐inspired tissue adhesive. Robert Langer (Department <strong>of</strong> Chemical Engineering, MassachusettsInstitute <strong>of</strong> Technology, MIT, EUA), Jeffrey Karp (Harvard‐MIT Division <strong>of</strong> Health Science <strong>and</strong>Technology, USA), Maria Pereira, Lino Ferreira (<strong>CNC</strong>, Portugal).Grid Warehousing <strong>and</strong> Data Mining <strong>of</strong> Protein Unfolding Simulations. Pr<strong>of</strong>essor Werner Dubitzky(University <strong>of</strong> Ulster, UK), Rui Brito (<strong>CNC</strong>, Portugal).Lentiviral vectors‐mediated ataxin‐3 gene silencing. Nicole Déglon, Philipe Hantraye (URA CEA‐CNRS2210, Service Hospitalier Frederic Joliot, MIRCen Program, Departement de Recherches Medicales,Direction des Sciences du Vivant, Commissariat a lʹEnergie Atomique (CEA), 91401 Orsay Cedex, France),Luís Almeida (<strong>CNC</strong>, Portugal).Lipoplex <strong>and</strong> peptide‐based delivery <strong>of</strong> steric‐block oligonucleotides <strong>and</strong> application in splice correction.Bernard Lebleu (University <strong>of</strong> Montpellier 2, UMR 5124 CNRS, Montpellier, France), M. ConceiçãoPedroso de Lima (<strong>CNC</strong>, Portugal).Models <strong>of</strong> Machado‐Joseph disease. Veronica Colomer, John Hopkins (School <strong>of</strong> Medicine, Baltimore,USA) Luís Pereira de Almeida (<strong>CNC</strong>, Portugal).Nanomaterials <strong>for</strong> cell tracking. John Martin (Centre <strong>for</strong> Cardiovascular Biology <strong>and</strong> Medicine, UniversityCollege <strong>of</strong> London, UK), Renata Gomes (<strong>CNC</strong>, Portugal), Lino Ferreira (<strong>CNC</strong>, Portugal).97Plant proteases <strong>for</strong> food industry. Dra. Nora Priolo, S<strong>and</strong>ra Vairo (LIPROVE, Universidade de La Plata,Argentina), Carlos Faro (<strong>CNC</strong>, Portugal).Pollen Proteases <strong>and</strong> Allergy. Dr. Sónia Barbensis, Cristina Barcia (Universidade San Luís, Argentina),Carlos Faro (<strong>CNC</strong>, Portugal).Pr<strong>of</strong>iling <strong>of</strong> the metabolism <strong>of</strong> proliferating cells. Craig Thompson (University <strong>of</strong> Pennsylvania, U.S.A.),Armindo Salvador (<strong>CNC</strong>, Portugal).Protein docking <strong>and</strong> drug design. Doctor Richard Michael Jackson (Leeds University, UK), Rui Brito(<strong>CNC</strong>, Portugal).Protein structure <strong>and</strong> dynamics using high field, multidimensional solution NMR. Doctor ChristinaRedfield (Ox<strong>for</strong>d University, UK), Rui Brito (<strong>CNC</strong>, Portugal).Protein structure using high field solid state NMR. Pr<strong>of</strong>essor Hartmut Oschkinat (Leibniz‐Institut fürMolekulare Pharmakologie, Berlin, Germany), Rui Brito (<strong>CNC</strong>, Portugal).Cell <strong>and</strong> Molecular ToxicologyA Biophysical Approach to the Role <strong>of</strong> Lipids in Hepatic Mitochondrial Toxicity. Catherine Brenner(University <strong>of</strong> Versailles/St Quentin, France), Teresa Pinheiro (Department <strong>of</strong> Biological Sciences,University <strong>of</strong> Warwick, UK), M.ª Amália Jurado, Paulo J. Oliveira (<strong>CNC</strong>, Portugal).
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General ObjectivesThe CNC major mis
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OrganizationThe Center for Neurosci
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Microbiology | Milton CostaMicrobio
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per year) will be proposed by the g
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Neuroprotection and Neurogenesis in
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Retinal Dysfunction and Neurogenesi
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Glutamatergic synapses | Head: Ana
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Neuronal Cell Death and Neuroprotec
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Molecular Mechanisms of Disease | H
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PublicationsAgasse F, Bernardino L,
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Santiago AR, Carvalho, CM, Carvalho
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Vectors and Gene Therapy GroupM. Co
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Molecular Systems Biology | Head: A
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Vectors and Gene Therapy | Head: Ma
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PublicationsAlves S, Nascimento‐F
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Area C | Cell and Molecular Toxicol
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Proteases aspárticas secretadas em
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Clivagem dos transportadores vesicu
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ʺBIOINK ‐ Aprendizagem increment
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154
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Henrique Faneca (Auxiliar Inv., CNC
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Liliana Bernardino 100Luis Miguel E
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Patricia Henriques Domingues 100Pat
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ADMINISTRATIVE STAFFTime % at CNCAr
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Sandra Isabel M. Cardoso (Auxiliar
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Molecular Biotechnology and HealthE
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Cell and Molecular ToxicologyLeonor
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MicrobiologyMilton Costa, PhD, Coor
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