Annual Report of Activities CNC 2008 - Center for Neuroscience and ...
Annual Report of Activities CNC 2008 - Center for Neuroscience and ...
Annual Report of Activities CNC 2008 - Center for Neuroscience and ...
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MICROSCOPY UNITHead <strong>of</strong> Unit: Luísa Cortes | PhD in Enzymology (2006) at University <strong>of</strong> CoimbraHead <strong>of</strong> Facility since 2007The Microscopy Unit provides technicalsupport on the investigation made usingLight Microscopy. Besides managing theresources, the unit assists in planningmicroscopy oriented projects, analysingexperimental results, processing acquiredimages <strong>and</strong> presenting data.Presently, the unit manages a laserscanning confocal microscope (Zeiss LSM510 Meta), a P.A.L.M. lasermicrodissecting microscope, a single cellcalcium imaging system, 2 widefieldsystems <strong>and</strong> other brightfieldmicroscopes. The systems are prepared<strong>for</strong> advanced applications which includelive cell imaging <strong>and</strong> single cell calciummeasurements, enabling the researchers<strong>of</strong> imaging dynamic events <strong>and</strong> molecularinteractions.The P.A.L.M. laser dissecting microscopeis a perfect tool <strong>for</strong> the isolation <strong>of</strong>different cell populations within a sample,allowing its full characterization. Usingthis technology, collaboration has beenestablished, with the service <strong>of</strong>Anatomical Pathology from the FMUC,with the aim <strong>of</strong> studying the differences<strong>of</strong> gene expression between tumour cellsat diverse stages.P.A.L.M. laser microdissecting microscopeLaser scanning confocal microscope127
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