Annual Report of Activities CNC 2008 - Center for Neuroscience and ...

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per year) will be proposed by the groups of the Neuroscience and Disease Line. Members of theNeuroscience and Disease area also participated as Faculty members at MIT‐Portugal PhD Programmeinvolving other Portuguese research Units (ITQB/IGC, IST, University of Minho, BIAL).Mitochondria and Cell Death group will be involved in organization and teaching in the “2009 PENSSummer School‐ Metabolic Aspects of Chronic Brain Disorders”, that will be held in Gunzburg, Germany(organizing committee: Patrick Weydt, Germany, Asa Petersen, Sweden, Ana Cristina Rego, Portugal,Maja Bresjanac, Slovenia).An international Symposium on “Crosstalk Between Basic and Clinical Research”, involving CNC groupsand the Neurological Clinic, Coimbra University Hospital, is being proposed for 2010.A patent resulting from the collaboration between different groups at CNC and the University of Minho ‐Silva B., Oliveira PJ, Dias ACP, Malva JO: Neuroprotection by phenolic compounds present in hypericumperforatum extracts. US Provisional PAT‐US 61/020,226.Future PlansThe wealth of expertise in studying glutamatergic synapses, mainly focused on glutamate receptorstrafficking and synaptic stabilization, regulation of their functional properties, either by purines,neuropeptides or phosphorylation, the role of mitochondria dysfunction and changes in interorganellecrosstalk will be further explored, to look at synaptic dysfunction and excitotoxic cell death that have beenobserved in several neurodegenerative diseases, stroke and epilepsy. We plan to expand the competitiveongoing research on the molecular determinants of neurodegeneration, neuroprotection and neurogenesis,from the molecular and cellular level to in vivo animal models of disease with impact on human carestrategies and offer competitive research service facilities to pharmaceutical industry.Future strategicdevelopment of research activity will be based on three main pillars: Neuroprotective strategies; Novelapproaches of brain repair based in gene therapy; The use of stem and progenitor cells for brain repair.Accordingly, we will pursue the study of the molecular and cellular basis of neuroprotection induced bymodulators of synaptic function, including classic neuromodulators, neurotrophins and downstreamantioxidant and mitoprotective mechanisms. New exciting developments of neuroprotection and neuraltissue repair using gene delivery created the basic conditions to develop strong research groups devoted tothe use of viral vectors and gene delivery as tools to stop the progression of brain diseases. Moreover, theuse of stem cells and particularly neural stem/progenitor cells will contribute to develop novel approachesable to promote the replacement of death neurons and oligodendrocytes, with new functional cells, inmodels of brain diseases.The close collaboration with the Neurology and Ophtalmology departments at the University Hospitalwill support the research using human tissues. This integrated approach will require the creation orupdating of research units such as neuroproteomics, electrophysiology, viral vectors and gene therapy,microdyalisis experimental surgery and behaviour studies. To meet the needs of the use of geneticallymodified animals as models of disease, the expansion and re‐organization of the animal facility is apriority16
Neuromodulation GroupRodrigo A. Cunha(PhD – Head of group)Paula G. AgostinhoAttila KöfalviLisiane O. PorciúnculaGeanne M. CunhaManuella P. KasterPaula M. CanasAna Patrícia SimõesCarla Sofia G. SilvaRui SanchesPedro Manuel V. GarçãoMarco António P. MatosElisabete O. AugustoPablo PandolfoAlexandre S. RodriguesSamira C. Ferreira(PhD)(PhD)(PhD)(PhD)(Post‐Doctoral Fellow)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)17Glutamatergic Synapses GroupAna Luísa Carvalho(PhD – Head of group)Tatiana CatarinoJoana FerreiraLuís Ribeiro(PhD Student)(PhD Student)(PhD Student)Carlos Adriano A. Matos (MSc Student)
Page 7 and 8: General ObjectivesThe CNC major mis
Page 11 and 12: OrganizationThe Center for Neurosci
Page 13: Microbiology | Milton CostaMicrobio
Page 18 and 19: Neuroprotection and Neurogenesis in
Page 20 and 21: Retinal Dysfunction and Neurogenesi
Page 22 and 23: Glutamatergic synapses | Head: Ana
Page 24 and 25: Neuronal Cell Death and Neuroprotec
Page 26 and 27: Molecular Mechanisms of Disease | H
Page 28 and 29: PublicationsAgasse F, Bernardino L,
Page 30 and 31: Santiago AR, Carvalho, CM, Carvalho
Page 32 and 33: “Nano‐transportadores de base l
Page 34 and 35: Vectors and Gene Therapy GroupM. Co
Page 36 and 37: Molecular Systems Biology | Head: A
Page 38 and 39: Vectors and Gene Therapy | Head: Ma
Page 40 and 41: PublicationsAlves S, Nascimento‐F
Page 43 and 44: Area C | Cell and Molecular Toxicol
Page 45 and 46: Mitochondrial Toxicology and Pharma
Page 47: Pharmacometrics GroupAmílcar Falc
Page 50 and 51: Free Radicals and Antioxidants in B
Page 52 and 53: Pharmacometrics | Head: Amílcar Fa
Page 54 and 55: Correia S, Carvalho C, Santos MS, P
Page 57 and 58: Area D | MicrobiologyCoordinator |
Page 59: Microbiology of Extreme Environment
Page 62 and 63: Medical Mycology - Yeast Research |
Page 65 and 66: Area E | Biophysics and Biomedical
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Inorganic Biochemistry and Molecula
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Inorganic Biochemistry and Molecula
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Cell Biophysics |Head: Luís Martin
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Sobral AJFN, Justino LLG, Santos AC
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Future PlansThere is an enormous we
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Paula MotaSara M. Diniz Martins Lop
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Biology of Reproduction and Human F
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Insulin Resistance and Adipocyte |
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Biomedical Inter‐Institutional Re
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3. Pediatric Research: metabolic di
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PublicationsSantos MJ, Cleto S, Men
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7. Research in brain cancer: geneti
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Grafting SVZ neural stem cell cultu
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Structure‐function analysis of th
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Anticancer Effects of of Phytochemi
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Investigaciones Biomédicas “Albe
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Participation in the organization o
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May 2008Member of the organizing co
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Genome BiologyFebruary 25 ‐ 27Isa
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Seminars2008 Series | CNC Audithori
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13.6.2008Cells caught in the act: M
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5.12.2008Unexpected fate and functi
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Elisabete Ferreiro“Cross‐talk b
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Ana Isabel Vicente Rafael“Estudos
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Rosete Pais“Papilomavirus humano
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FLOW CYTOMETRY UNITHead of Unit: Is
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MASS SPECTROMETRY UNITHead of Unit:
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Amino Acid AnalysisOur laboratory r
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2. Areas of Expertise / Research /
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Multiple SclerosisAn extension of t
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2.2. Centre for Bioavailability Stu
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StaffCoordinatorTice Macedo, MD, Ph
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Compatible solutes from extremophil
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Proteases aspárticas secretadas em
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Mecanismos de plasticidade sinápti
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Clivagem dos transportadores vesicu
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ʺBIOINK ‐ Aprendizagem increment
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Henrique Faneca (Auxiliar Inv., CNC
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Liliana Bernardino 100Luis Miguel E
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João Teixeira 100João Teodoro 100
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Patricia Henriques Domingues 100Pat
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ADMINISTRATIVE STAFFTime % at CNCAr
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Sandra Isabel M. Cardoso (Auxiliar
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Molecular Biotechnology and HealthE
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Cell and Molecular ToxicologyLeonor
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MicrobiologyMilton Costa, PhD, Coor
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Paulo Gameiro Guerreiro 100Pedro Co
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Marta Isabel Rodrigues Baptista 100
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Url: http://www.cnbc.pt | Email: in
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