Annual Report of Activities CNC 2008 - Center for Neuroscience and ...

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Future ResearchThis Area carried out the 4th edition of the “International Courses on Toxicology at the CNCʺ, organizedon a yearly basis, entitled ʺMetabolic Toxicology, From Pathway to Organismʺ, which had theparticipation of highly recognized scientists: Vitor M. C. Madeira (Portugal), Yvonne Will (USA), ElaineHolmes (UK), Piero Portincasa (Italy), Maria de Lourdes Bastos (Portugal), Rui A. Carvalho (Portugal),Carlos M. Palmeira (Portugal) (April 9‐11, 2008).Future PlansThis area is maintaining a focus on the study of cellular and molecular basis of disease as well as druginducedcell toxicity, in which mitochondria, lipid membrane or free radicals could be involved, for thepurpose of translating this knowledge into disease treatment and prevention. Future research plansencompass mainly the continuation of ongoing research and new objectives, including the use of noveltechniques and biological and non‐biological models, as specified by each group. Also, the recently createdgroup, Pharmacometrics, is bringing into the CNC the expertise on developing and applying mathematicaland statistical methods to a better understanding and prediction of drug pharmacokinetic andpharmacodynamic behaviour, which are critical for optimizing drug efficacy and minimizing its toxicity.In silico techniques are becoming now popular in drug discovery and drug toxicolgy. Optimization ofsuch approaches and the potential synergism with other groups within CNC constitute a great challengein near future. It is worthy of note that besides the ongoing basic research from the molecular and cellularlevel to in vivo animal models, as specified by each group, future research plans encompass also sometranslational research. In fact, a few lines of research are currently working in the borderline between thebench and the bedside and all the groups are pushing forward some translational research projects in anear future.On the other hand, aware of the relevance of the cohesion and synergy within the area, a trend is beingimplemented to conjugate the expertise of groups. Also, we are engaged in expanding the network ofcollaborations within the CNC and abroad. A great effort will be done to maintain the organization of theannual International Courses on Toxicology at CNC with the participation of highly recognized scientists.The organization of conferences and advanced courses, mainly in the scope of the CNC DoctoralProgramme, by joining the efforts of the research groups will be stimulated.44
Mitochondrial Toxicology and Pharmacology GroupPaulo J. Oliveira(PhD – Head of group)José CustódioMaria S. SantosCarlos M. PalmeiraAnabela P. RoloVilma A. OliveiraAna BurgeiroAna Filipa BrancoGonçalo PereiraInês BarbosaTeresa SerafimAna Patricia S. GomesAna Teresa I. VarelaSandro PereiraJoão MonteiroCláudia PereiraCátia DiogoFilipe DuarteJoão TeodoroSusana CardosoCristina CarvalhoSusana PereiraAnabela SimõesNuno Gabriel MachadoAna Carolina MoreiraFilipa CarvalhoRicardo MarquesTiago Capote(PhD)(PhD)(PhD)(Post‐Doctoral Fellow)(Post‐Doctoral Fellow)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(PhD Student)(Grant Technician)(Grant Technician)(MSc Student)(MSc Student)(MSc Student)(MSc Student)(MSc Student)45
Page 7 and 8: General ObjectivesThe CNC major mis
Page 11 and 12: OrganizationThe Center for Neurosci
Page 13: Microbiology | Milton CostaMicrobio
Page 16 and 17: per year) will be proposed by the g
Page 18 and 19: Neuroprotection and Neurogenesis in
Page 20 and 21: Retinal Dysfunction and Neurogenesi
Page 22 and 23: Glutamatergic synapses | Head: Ana
Page 24 and 25: Neuronal Cell Death and Neuroprotec
Page 26 and 27: Molecular Mechanisms of Disease | H
Page 28 and 29: PublicationsAgasse F, Bernardino L,
Page 30 and 31: Santiago AR, Carvalho, CM, Carvalho
Page 32 and 33: “Nano‐transportadores de base l
Page 34 and 35: Vectors and Gene Therapy GroupM. Co
Page 36 and 37: Molecular Systems Biology | Head: A
Page 38 and 39: Vectors and Gene Therapy | Head: Ma
Page 40 and 41: PublicationsAlves S, Nascimento‐F
Page 43: Area C | Cell and Molecular Toxicol
Page 47: Pharmacometrics GroupAmílcar Falc
Page 50 and 51: Free Radicals and Antioxidants in B
Page 52 and 53: Pharmacometrics | Head: Amílcar Fa
Page 54 and 55: Correia S, Carvalho C, Santos MS, P
Page 57 and 58: Area D | MicrobiologyCoordinator |
Page 59: Microbiology of Extreme Environment
Page 62 and 63: Medical Mycology - Yeast Research |
Page 65 and 66: Area E | Biophysics and Biomedical
Page 67 and 68: Inorganic Biochemistry and Molecula
Page 69 and 70: Inorganic Biochemistry and Molecula
Page 71 and 72: Cell Biophysics |Head: Luís Martin
Page 73: Sobral AJFN, Justino LLG, Santos AC
Page 76 and 77: Future PlansThere is an enormous we
Page 78 and 79: Paula MotaSara M. Diniz Martins Lop
Page 80 and 81: Biology of Reproduction and Human F
Page 82 and 83: Insulin Resistance and Adipocyte |
Page 85 and 86: Biomedical Inter‐Institutional Re
Page 87 and 88: 3. Pediatric Research: metabolic di
Page 89 and 90: PublicationsSantos MJ, Cleto S, Men
Page 91: 7. Research in brain cancer: geneti
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Grafting SVZ neural stem cell cultu
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Structure‐function analysis of th
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Anticancer Effects of of Phytochemi
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Investigaciones Biomédicas “Albe
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Participation in the organization o
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May 2008Member of the organizing co
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Genome BiologyFebruary 25 ‐ 27Isa
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Seminars2008 Series | CNC Audithori
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13.6.2008Cells caught in the act: M
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5.12.2008Unexpected fate and functi
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Elisabete Ferreiro“Cross‐talk b
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Ana Isabel Vicente Rafael“Estudos
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Rosete Pais“Papilomavirus humano
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FLOW CYTOMETRY UNITHead of Unit: Is
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MASS SPECTROMETRY UNITHead of Unit:
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Amino Acid AnalysisOur laboratory r
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2. Areas of Expertise / Research /
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Multiple SclerosisAn extension of t
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2.2. Centre for Bioavailability Stu
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StaffCoordinatorTice Macedo, MD, Ph
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Compatible solutes from extremophil
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Proteases aspárticas secretadas em
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Mecanismos de plasticidade sinápti
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Clivagem dos transportadores vesicu
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ʺBIOINK ‐ Aprendizagem increment
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Henrique Faneca (Auxiliar Inv., CNC
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Liliana Bernardino 100Luis Miguel E
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João Teixeira 100João Teodoro 100
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Patricia Henriques Domingues 100Pat
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ADMINISTRATIVE STAFFTime % at CNCAr
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Sandra Isabel M. Cardoso (Auxiliar
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Molecular Biotechnology and HealthE
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Cell and Molecular ToxicologyLeonor
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MicrobiologyMilton Costa, PhD, Coor
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Paulo Gameiro Guerreiro 100Pedro Co
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Marta Isabel Rodrigues Baptista 100
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Url: http://www.cnbc.pt | Email: in
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