Community Medicine Abstracts - College of Medicine and Health ...

Project No. 123 (1997)Role of Helicobacter Pylori Infection Among Dyspeptic Patients Attending AlAin Hospital, Al AinStudent Authors: Huda Khalid Saeed Al AwadiFaculty Supervisors: Dr. N. Pugh, Dr. F. Al MaskariAbstract:Objectives Helicobacter pylori is an important cause of chronic active gastritis and isstrongly associated with peptic ulcer disease and gastric cancer. To estimate theprevalence of H.pylori infection in patients who underwent upper gastrointestinalendoscopy and biopsy and to identify the factors which may influence the prevalenceand to document the outcome of specific treatment regimen.Methods This retrospective study of all patients attending for endoscopy investigationin Al Ain hospital during 2 January1997 to 24 March 1997.Results A total of 163 cases were studied (75.46% males and 24.54% females) out ofwhich only 100 cases had biopsy. 62% of those with biopsy were +ve for H. pyloriinfection, 38% were –ve for the infection. Of the +ve cases , The Gulf Arabs comprisedof 15%, 17% comprised of other Arabs and 30% comprised other nationalities.H.pylori was detected in 100% of severe cases, 66.6% of moderate cases and 31.8%of mild cases. The most effective eradicative method for the bacteria was found to bea combination of omeprazole, amoxycillin and erythromycin (55.56% of total 6 casestreated with this regimen) followed by a combination of omeprazole and amoxycillin(747.06% of total 17 cases treated with this regimen).Conclusions Helicobacter pylori is an important and common human pathogen causinggastritis, peptic ulcer (duodenal ulcer), and gastric malignancy. Effective eradicationprevents mortality and morbidity associated with peptic ulcer disease. Whether italters malignancy needs to be researched. Further refinements of therapy arerequired as well as the development of effective methos for the prevention of theinfection.