computer modeling in molecular biology.pdf

HLA-B*270 IHLA-B*2702HLA-B*2703HLA-B*2704HLA-B*2705HLA-B'2706HLA-B*2707HLA-B*2701HLA-B*2702HLA-B*2703HLA-B*2704HLA-B*2705HLA-B*2706HLA-B*2707HLA-B *2701HLA-B.2702HLA-B'2703HLA-B *2704HLA-B.2705HLA-B*2706HLA-B.2707(a)7 Major Histocompatibility Complex Class I Protein-Peptide Interactions201-60606060606060120120120120120120120182182182182182182182Figure 7-16. (a) Sequence alignment of the seven HLA-B27 subtype molecules. From HLA-B*2705, the archetypal HLA-B27 allele the evolution of all other seven molecules can bedefined. (b) Molecular graphics image of HLA-B*2705 displaying, in dark-grey, patches theregions of polymorphism. The clustering of polymorphic residues in the regions that surroundand chelate the C-terminal residue PC, and the penultimate residue PC-1 (P8 in a nonamersuch as the EBNA 3C epitope) is clearly visible.