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2 Modell<strong>in</strong>a Prote<strong>in</strong> Structures 33AcknowledgementsTJPH thanks the Medical Research Council and Zeneca Pharmaceuticals and AMLthanks the Kay Kendall Foundation for generous support.References[l] Anf<strong>in</strong>sen, C. B., Science 1973, 181, 223-230.[2] Hubbard, T. J., Sander C., Prote<strong>in</strong> Eng. 1991, 4, 711-717.[3] Karplus, M., Petsko, G. A., Nature 1990, 347, 631-639.[4] Barton, G. J., Sternberg, M. J., Prote<strong>in</strong> Eng. 1987, I, 89-94.[5] Ploegman, J. H., et al., J. Mol. Biol. 1978, 123, 557-565.[6] Chothia, C., Lesk, A. M., EMBO J. 1986, 5, 823-826.[7] Hubbard, T. J., Blundell, T. L., Prote<strong>in</strong> Eng. 1987, I, 159-171.[8] Flaherty, K. M. et al., Proc. Natl. Acad. Sci. USA 1991, 88, 5041-5045.[9] Kabsch, W., Sander, C., Proc. Natl. Acad. Sci. USA 1984, 81, 1075-1078.[lo] Bork, P. et al., Prote<strong>in</strong> Sci. 1992, 1, 1677-1690.[Ill Bork, P. et aI., Nature 1992, 358, 287.[12] Benner, S. A., Gerloff, D., Adv. Enz. Regul. 1990, 31, 121-181.[13] Rost, B., Sander, C., Nature 1992, 360.[14] Rost, B. et al., TZBS 1993, 18, 120-123.[15] Chothia, C., Nature 1992, 357, 543-544.[16] Pastore, A., Lesk, A. M., Curr. Op<strong>in</strong>. Biotech. 1991, 2, 592-598.[17] Bernste<strong>in</strong>, F. C., et al., .I Mol. Biol. 1977, 112, 535-542.[18] Abola, E. et al., <strong>in</strong>: Crystallographic Databases - Information Content, SoftwareSystems, Scientific Applications, Allen, F. H., et al., (eds.), Data Commission of the InternationalUnion of Crystallography, Bonn/Cambridge/Chester, 1987, pp. 107- 132.[19] Hobohm, U. et al, Prote<strong>in</strong> Sci. 1992, 1, 409-417.[20] Holm, L. et al., Prote<strong>in</strong> Sci. 1992, 1, 1691-1698.[21] Bairoch, A., Boeckmann, B., Nucl. Acids Res. 1991, 19, 2247-2250.[22] Sander, C., Schneider, R., Prote<strong>in</strong>s 1991, 9, 56-68.[23] Argos, P., et al. Prote<strong>in</strong> Eng. 1991, 4, 375-383.[24] von Heijne, G., Eur. J. Biochem. 1991, 199, 253-256.[25] Bairoch, A., Nucl. Acids Res. 1992, 20 (Suppl.), 2013-2018.[26] Sibbald, P. R., Argos, P., Comput. Appi. Biosci. 1990, 6, 279-288.[27] Pearl, L. H., Taylor, W. R., Nature 1987, 329, 351-354.[28] Over<strong>in</strong>gton, J. et al., Proc. R. SOC. London B. 1990, 241, 132-145.[29] Luethy, R. et al., Prote<strong>in</strong>s 1991, 10, 229-239.[30] Bowie, J. U. et al., Science 1991, 253, 164-170.[31] Over<strong>in</strong>gton, J. et al., Prote<strong>in</strong> Sci. 1992, I, 216-226.[32] Sippl, M. J., J. Mol. Biol. 1990, 213, 859-883.[33] F<strong>in</strong>kelste<strong>in</strong>, A. V., Reva, B. A., Nature 1991, 351, 497-499.[34] Sippl, M. J., Weitckus, S., Prote<strong>in</strong>s 1992, 13, 258-271.[35] Jones, D. T., et al., Nature 1992, 358, 86-89.[36] Bryant, S. H., Lawrence, C. E., Prote<strong>in</strong>s 1993, 16, 92-112.

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