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in Albania - Instituti i Shendetit Publik

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ALBANIAN MEDICAL JOURNAL SUPPLEMENTCorrelation between AAN, anti DNA, C3 and C4 withdisease activity <strong>in</strong> Systemic Lupus ErythematosusErgeta Ktona 1 , Myftar Barbullushi 2 , Teuta Backa 3 , Enver Roshi 4,5 ,Alma Idrizi 2 , Valbona Bajrami 11Ikeda DC, Tirana, <strong>Albania</strong>;2Nephrology Service, University Hospital Center Mother Teresa , Tirana, <strong>Albania</strong>;3Rheumatology Service, University Hospital Center Mother Teresa , Tirana, <strong>Albania</strong>;4Faculty of Public Health, University of Medic<strong>in</strong>e, Tirana, <strong>Albania</strong>;5Institute of Public Health, Tirana, <strong>Albania</strong>.Aim: The aim of this study was to determ<strong>in</strong>e thecorrelations between ant<strong>in</strong>ucleosome antibodies(ANA) and anti-double-stranded (ds) DNAantibodies, complement (C) 3 and 4 levels, andcl<strong>in</strong>ical activities <strong>in</strong> Systemic Lupus Erythematosus(SLE) patients.Methods: Ant<strong>in</strong>ucleosome antibodies and antidsDNAantibodies were detected by enzyme-l<strong>in</strong>kedimmunosorbent assays (ELISA). The levels of C3and C4 were measured by nephelometry. Cl<strong>in</strong>icalactivities were determ<strong>in</strong>ed by SLE cl<strong>in</strong>ical andlaboratory test <strong>in</strong> collaboration with Disease ActivityIndex.Results: Among 96 SLE patients, the prevalenceof AAN was 54.1% (n=52 patients), higher than38.5% (n=37 patients) [p

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