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Interventions for Tuberculosis Control and Elimination 2002

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Relative risk (log scale)<br />

10<br />

3<br />

1<br />

0.5<br />

0.2<br />

Ref<br />

0<br />

1 - 5 6 - 10 11 - 15 16 - 20 20 +<br />

Induration (mm)<br />

Figure 74. Risk of tuberculosis during follow-up by size of initial tuberculin skin<br />

test reaction, Karonga District, Malawi. Reproduced from 831 by the permission of<br />

the publisher Elsevier Science.<br />

of T cell proliferation <strong>and</strong> interferon-gamma production. This could explain<br />

to some extent the reduced efficacy of BCG in countries in the world where<br />

helminthic infestation is common. 836<br />

Number of reported cases<br />

80<br />

60<br />

40<br />

20<br />

0<br />

Discontinuation of mass<br />

BCG vaccination<br />

70 75 80 85 90<br />

Year of report<br />

Figure 75. Reported cases of mycobacteriosis due to M. avium complex, Sweden,<br />

1969-1993. Data courtesy Victoria Romanus, Swedish Institute <strong>for</strong> Infectious Diseases.<br />

122

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