Interventions for Tuberculosis Control and Elimination 2002

twice rather than once per day, reduce the frequency of adverse drug events.
Stevens-Johnson syndrome has been reported in an HIV-infected patient. 1025
Cycloserine appears to interact with alcohol, increasing the toxic effects
of alcohol. 1026
Determination of resistance to cycloserine is difficult, and the correspondence
of laboratory results with clinical data is poor (figure 90). 466
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Figure 90. Proportion of strains of M. tuberculosis from resected lungs, in vitro
resistant to anti-tuberculosis drugs, as a function of duration of treatment, the strain
containing no susceptible organisms. Reproduced from 466 by the permission of the
publisher American Thoracic Society at the American Lung Association.
Para-aminosalicylic acid
In 1940, Bernheim demonstrated that salicylic acid and benzoic acid
increased the oxygen consumption and carbon dioxide production of
M. tuberculosis. 1027 Based on these observations, Lehmann investigated
more than 50 derivatives of benzoic acid with the purpose of finding a substance
possessing activities against M. tuberculosis. The most active compound
he identified in the experiments was para-aminosalicylic acid, first
published as preliminary results in the Lancet in 1946. 1028 Soon thereafter
the first reports appeared, demonstrating its considerable anti-tuberculosis