Interventions for Tuberculosis Control and Elimination 2002

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Because of this strong association, thioacetazone should never be given
to patients known to be HIV infected. 13 It is also sensible policy to relinquish
its use in countries where the HIV prevalence among tuberculosis
patients is known to be high. 449,450
Interactions. Interactions between thioacetazone and other medications are
not known.
Fixed-dose combinations
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Figure 29. Adverse cutaneous reactions and deaths associated with the use of
thioacetazone, by duration of thioacetazone intake. Tanzania National Tuberculosis
/ Leprosy Programme and IUATLD, unpublished data.
Tuberculosis needs to be treated with multiple drugs. It is thus not surprising
that efforts have been undertaken to develop so called fixed-dose
combinations. Fixed-dose combinations simplify treatment, minimize prescription
errors, and simplify supply management. 191,451 As fixed-dose combinations
containing rifampicin may be particularly prone to posing difficulties
in assuring bioavailability, specific requirements have been outlined
to ensure their quality. 452,453
The dosages of the individual components in a fixed-dose combination
are of critical importance to prevent both over- and under-dosage. The
WHO recommends the dosages per tablet as summarized in table 8. 454,455
49