Interventions for Tuberculosis Control and Elimination 2002

Per cent positive
100
80
60
40
20
0
0 4 8 12 16 20
Isoniazid plus thioacetazone
Month of treatment
In East Africa, a comparison of 12-month regimens was carried out with
isoniazid plus thioacetazone throughout, one arm containing streptomycin
during the first two months and another arm without streptomycin. 501 It
was demonstrated that the two-month supplement of streptomycin contributed
to a higher cumulative conversion rate (figure 47).
65
INH+PAS
INH+EMB
Figure 46. Sputum conversion among patients receiving isoniazid and para-aminosalicylic
acid compared to isoniazid and ethambutol. 484
Per cent culture positive
100
80
60
40
20
0
12 TH
2 STH / 10 TH
0 2 4 6 8 10 12
Month after start of treatment
Figure 47. Effect on culture conversion of adding two months of streptomycin to
a 12-month regimen of isoniazid and thioacetazone. 501