VACCINE

Developments In Biologicals (Basel) • 2006
Vaccine cell substrates:
bovine and porcine virus considerations
Author information
Wessman SJ
USDA, APHIS, VS
Center for Veterinary Biologics
Ames, Iowa 50010, USA
stephen.j.wessman@aphis.usda.gov
Abstract
The use of materials of animal origin to supplement cell cultures used in vaccine
production, viral diagnostic testing, or materials testing may lead to contamination
of the vaccines, with seroconversion or disease in the vaccinated
animals, and possible misdiagnosis of diagnostic samples or incorrect test results.
The methods used by the Center for Veterinary Biologics to monitor serum
and cell cultures are described. Considerations for the use of animal origin
materials, especially bovine and porcine, as substrates or additives, plus the
possibility of crossovers to humans are discussed.
“The use of materials of animal origin
to supplement cell cultures used in
vaccine production, viral diagnostic
testing, or materials testing may lead
to contamination of the vaccines, with
seroconversion or disease in the
vaccinated animals, and possible
misdiagnosis of diagnostic samples
or incorrect test results.”
http://www.ncbi.nlm.nih.gov/pubmed/16566453