VACCINE

Clinical Science • London England • November 1989
Effect of aluminium on superoxide dismutase
Author information
Shainkin-Kestenbaum R1,
Adler AJ, Berlyne GM, Caruso C.
Nephrology Section
Brooklyn VA Medical Center
New York 11209
Abstract
1. The effect of Al3+ on superoxide dismutase in vitro was studied, since in
uraemia there is excessive superoxide production and frequently an elevated serum
Al3+ level. Thus, the protective role of superoxide dismutase is particularly
important.
2. Al3+ in concentrations similar to those found in the serum of uraemic patients
inhibits superoxide dismutase activity. The degree of inhibition is directly proportional
to the Al3+ level.
3. The combination of excessive oxygen free radical production with an increased
Al3+ level may contribute to a variety of complications, including aluminium
dementia or initiation and promotion of carcinogenic processes, which
are known to be more common in uraemic patients.
http://www.ncbi.nlm.nih.gov/pubmed/2582719
“The combination of
excessive oxygen free radical production
with an increased aluminum level may contribute
to a variety of complications, including aluminium
dementia or initiation and promotion
of carcinogenic processes ...”