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Harefuah • February 2015<br />

The sick building syndrome<br />

as a part of ‘ASIA’<br />

(autoimmune/auto-inflammatory syndrome induced by adjuvants)<br />

by Maoz-Segal R, Agmon-Levin N, Israeli E, Shoenfeld Y.<br />

Abstract<br />

The entity ‘sick building syndrome’ is poorly defined and comprises of a set<br />

of symptoms resulting from environmental exposure to a work or a living<br />

environment. The symptoms are mainly “allergic”-like and include nasal,<br />

eye, and mucous membrane irritation, dry skin as well as respiratory symptoms<br />

and general symptoms such as fatigue, lethargy, headaches and fever.<br />

The Autoimmune [Auto-inflammatory] Syndrome Induced by Adjuvants<br />

(ASIA) is a wider term which describes the role of various environmental<br />

factors in the pathogenesis of immune mediated diseases. Factors entailing<br />

an immune adjuvant activity such as infectious agents, silicone, aluminium<br />

salts and others were found in association with defined and non-defined<br />

immune mediated diseases. The sick building syndrome and ASIA share a<br />

similar complex of signs and symptoms and probably the same immunological<br />

mechanisms which further support a common denominator.<br />

“Factors entailing an immune adjuvant activity<br />

such as infectious agents, silicone, aluminium salts<br />

and others were found in association with defined<br />

and non-defined immune mediated diseases.”<br />

http://www.ncbi.nlm.nih.gov/pubmed/25856869

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