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“... some autism spectrum disorders may result from ... exposure to mercury.”<br />

Neuro Endocrinology Letters • December 2006<br />

A clinical trial<br />

of combined anti-androgen and anti-heavy metal therapy<br />

in autistic disorders<br />

Author information<br />

Geier DA1, Geier MR.<br />

Institute of Chronic Illnesses, Silver Spring, MD 20905, USA<br />

Abstract<br />

BACKGROUND<br />

A medical hypothesis has suggested that some autism spectrum disorders (ASDs) may result from interactions between the methionine<br />

cycle-transsulfuration and androgen pathways following exposure to mercury.<br />

METHODS<br />

The IRB of the Institute for Chronic Illnesses approved the present study. A novel treatment was utilized combining LUPRON<br />

(leuprolide acetate, TAP Pharmaceuticals, Inc.) and CHEMET (meso-2, 3-dimercaptosuccinic acid--DMSA, McNeil Consumer<br />

Products Company) on 11 consecutive children with ASDs.<br />

RESULTS<br />

A significant (p

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