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“Aluminum has been associated with several neurodegenerative diseases,
such as dialysis encephalopathy, amyotrophic lateral sclerosis and Parkinsonism dementia
in the Kii peninsula and Guam, and in particular, Alzheimer’s disease.”
Journal Of Alzheimers Disease • November 2005
Effects of aluminum on the nervous system
and its possible link with neurodegenerative diseases
Author information
Kawahara M.
Department of Analytical Chemistry
School of Pharmaceutical Sciences
Kyushu University of Health and Welfare
Nobeoka-city, Miyazaki, 882-8508, Japan
Abstract
Aluminum is environmentally abundant, but not an essential element. Aluminum has been associated with several
neurodegenerative diseases, such as dialysis encephalopathy, amyotrophic lateral sclerosis and Parkinsonism dementia
in the Kii peninsula and Guam, and in particular, Alzheimer’s disease. Although this association remains
controversial, there is increasing evidence which suggests the implication of metal homeostasis in the pathogenesis
of Alzheimer’s disease. Aluminum, zinc, copper, and iron cause the conformational changes of Alzheimer’s
amyloid-beta protein. Al causes the accumulation of tau protein and amyloid-beta protein in experimental animals.
Aluminum induces neuronal apoptosis in vivo as well as in vitro. Furthermore, a relationship between aluminum
and the iron-homeostasis or calcium-homeostasis has been suggested. Based on these findings, the characteristics
of aluminum neurotoxicity are reviewed, and the potential link between aluminum and neurodegenerative diseases
is reconsidered.
http://www.ncbi.nlm.nih.gov/pubmed/16308486