VACCINE

Toxicology • 1992
Role of aluminium
in skin reactions after
diphtheria-tetanus-pertussis-poliomyelitis vaccination:
an experimental study in rabbits
Author information
Pineau A1, Durand C, Guillard O, Bureau B, Stalder JF.
Laboratoire de Toxicologie et d’Hygiène Industrielle
Faculté de Pharmacie, Centre Hospitalier Régional Universitaire
Nantes, France
Abstract
The occurrence of subcutaneous nodules at the injection site is one of the complications
of diphtheria-tetanus-pertussis-poliomyelitis vaccination, but the causes and
mechanisms involved are still poorly understood. An experimental study in the New
Zealand rabbit enabled us to determine the frequency of occurrence of these nodules,
how long they persist and the histopathologic features of the cells involved. Aluminium
(Al) assays by electrothermal atomic absorption spectrometry allowed us to
study concentrations both in nodules and the organism (serum, normal skin). The results
show an absence of Al diffusion outside nodules, a correlation between infiltrate
intensity and Al concentration in nodules and modifications in the histological constituents
of nodule cells. The histological picture indicates a foreign body reaction
to Al. All these data underscore the role of Al in the formation of early postvaccinal
nodules at the injection site.
http://www.ncbi.nlm.nih.gov/pubmed/?term=1589878
“All these data
underscore the role of Aluminum
in the formation of early postvaccinal
nodules at the injection site.”
[this is one of the earliest examples of “nodules at the
injection site” mentioned in the medical literature. As
you’ll see, eventually this phenomenon leads to a new
disorder, Macrophagic Myofasciitis and the coining of
the term “ASIA,” a wide variety of nearly 100 recognized
autoimmune and inflammatory disorders induced by the
Aluminum adjuvant in vaccines]