VACCINE

“The use of materials of animal origin to supplement cell cultures used in vaccine production,
viral diagnostic testing, or materials testing may lead to contamination of the vaccines ...”
Developments In Biologicals (Basel) • 2006
Vaccine cell substrates: bovine and porcine virus considerations
Author information
Wessman SJ.
USDA, APHIS, VS, Center for Veterinary Biologics, Ames, Iowa 50010, USA
stephen.j.wessman@aphis.usda.gov
Abstract
The use of materials of animal origin to supplement cell cultures used in vaccine production, viral diagnostic
testing, or materials testing may lead to contamination of the vaccines, with seroconversion or disease in the vaccinated
animals, and possible misdiagnosis of diagnostic samples or incorrect test results. The methods used by
the Center for Veterinary Biologics to monitor serum and cell cultures are described. Considerations for the use
of animal origin materials, especially bovine and porcine, as substrates or additives, plus the possibility of crossovers
to humans are discussed.
http://www.ncbi.nlm.nih.gov/pubmed/16566453