VACCINE

Journal Of Infectious Disease • December 2015
The Decline of
Pertussis-Specific Antibodies
After Tetanus, Diphtheria, and Acellular Pertussis
Immunization in Late Pregnancy
Author information
Abu Raya B1, Srugo I2, Kessel A3,
Peterman M4, Vaknin A5, Bamberger E6.
1. Department of Pediatrics The Ruth and Bruce Rappaport Faculty of Medicine
Technion-Israel Institute of Technology, Haifa
2. Department of Pediatrics Clinical Microbiology Laboratory
The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa
3. Division of Allergy and Clinical Immunology, Bnai Zion Medical Center The Ruth and Bruce
Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa
4. Clinical Microbiology Laboratory
5. The Ruth and Bruce Rappaport Faculty of Medicine
Technion-Israel Institute of Technology, Haifa
6. Clinical Microbiology Laboratory The Ruth and Bruce Rappaport Faculty of Medicine
Technion-Israel Institute of Technology, Haifa
Abstract
We prospectively measured pertussis-specific antibodies 9-15 months after
delivery in women immunized with tetanus, diphtheria, and acellular pertussis
(Tdap) after the 20th week of their recent pregnancy. The Tdap-immunized
women (n = 38) exhibited a decline in geometric mean concentrations
between their peripartum and follow-up levels for immunoglobulin G
to pertussis toxin (21.48 [95% confidence interval, 12.51-36.89] vs 11.72
[7.09-19.37] IU/mL];); filamentous hemagglutinin (185.95 [157.93-218.94]
vs 140.33 IU/mL [113.46-173.57] IU/mL); and pertactin (171.52 [120.73-
243.67] vs 83.74 [60.58-115.75] IU/mL) (all P < .001). For women immunized
with Tdap during late pregnancy, pertussis-specific immunoglobulin
G levels decreased significantly 9-15 months after delivery.
“For women immunized with Tdap
during late pregnancy, pertussis-specific
immunoglobulin G levels decreased
significantly 9-15 months after delivery.”
http://www.ncbi.nlm.nih.gov/pubmed/26160743