VACCINE

Annals Of Dermatology And Venereology • August 2004
Granuloma with
lymphocytic hyperplasia
following vaccination: 10 cases
Presence of aluminium in the biopsies
Author information
Lafaye S1, Authier FJ, Fraitag S, Rethers L, Bagot M, Wechsler J.
Département de Pathologie, Hôpital Henri Mondor,
51 avenue du Maréchal de Lattre de Tassigny
94010 Créteil, France
Abstract
BACKGROUND
Few cases of cutaneous lymphocytic hyperplasia secondary to vaccination
have been published, although such lesions are not rare.
PATIENTS AND METHODS
We report a series of 10 cases registered between 1993 and 2003.
RESULTS
Mean age was 25. The clinical aspect was solitary or multiple subcutaneous
nodules, located on the arm, developing after a delay of 1 to
18 months after vaccination. Histologic examination showed a lymphocytic
infiltration of the subcutaneous fat, with diffuse and/or follicular
pattern, without nuclear atypia, the morphological and immunohistochemical
analysis of which revealed the benign nature. In all cases,
there was fibrosis and granuloma composed of lymphocytes, plasma
cells, eosinophils and macrophages with basophilic cytoplasm. Morin
stain showed intralesional aluminium in the 6 investigated cases. Evolution
was always benign, with no relapse following exeresis.
“Cutaneous lymphocytic hyperplasia
secondary to vaccination has to be suspected
in a young patient with subcutaneous nodules
appearing at a vaccination site. Evidence of
aluminium in the lesions supports the diagnosis ...”
DISCUSSION
Cutaneous lymphocytic hyperplasia secondary to vaccination has to be
suspected in a young patient with subcutaneous nodules appearing at
a vaccination site. Evidence of aluminium in the lesions supports the
diagnosis and the hypothesis that aluminium in the vaccine excipient
might have a role in the onset of such lesions.
http://www.ncbi.nlm.nih.gov/pubmed/?term=15505542