NAMS 2002 Workshop - ICOM 2008

More documents

Recommendations

Info

Biomedical and Biotechnology I – 3 Monday July 14, 10:45 AM-11:15 AM, Honolulu/Kahuku Bioactive Membranes for Liver Tissue Engineering L. De Bartolo (Speaker), Institute on Membrane Technology, National Research Council of Italy, ITM-C, Italy, l.debartolo@itm.cnr.it S. Salerno, Institute on Membrane Technology, National Research Council of Italy, ITM-C, Italy A. Piscioneri, Institute on Membrane Technology, National Research Council of Italy, ITM-C, Italy S. Morelli, Institute on Membrane Technology, National Research Council of Italy, ITM-C, Italy M. Rende, Institute on Membrane Technology, National Research Council of Italy, ITM-C, Italy C. Campana, Institute on Membrane Technology, National Research Council of Italy, ITM-C, Italy E. Drioli, Institute on Membrane Technology, National Research Council of Italy, ITM-C, Italy Biomaterials in tissue engineering and regenerative medicine should provide the necessary support for cells to proliferate and maintain their differentiated functions. The use of polymeric semipermeable membranes with different physico-chemical and transport properties is appealing in tissue engineering and bioartificial organs since these and biomembranes share similarities such as the selective transport of molecules, resistances and protection. Furthermore, synthetic membranes can easily be mass produced modulating their morphological and physico-chemical properties for specific applications. Semipermeable membranes for their characteristics of selectivity, stability and biocompatibility could provide a support for the maintenance of hepatocyte phenotype and differentiated functions. In this study we report on the synthesis of novel semipermeable membranes able to support the long-term maintenance and differentiation of human liver cells and on the strategies to optimise cellbiomaterial interactions in biohybrid systems. We developed membrane biohybrid system constituted by membranes made from a polymeric blend of modified polyetheretherketone and polyurethane (PEEK-WC-PU) and human hepatocytes. This membrane combines the advantageous properties of the polymers (i.e., biocompatibility, biostability and biofunctionalities) with those of membranes such as permeability, selectivity and well-defined geometry. Molecular modifications of the membrane elicit specific interactions with cell receptors and thereby enhance liver functions. Human hepatocytes organize in a 3D structure in the membrane biohybrid system maintaining a polygonal shape, which would lead to better functional maintenance, so many of the features of the liver in vivo are reconstituted. Liver specific functions investigated in terms of urea synthesis, albumin production and total protein secretion are maintained at high levels. Hepatocytes are able to biotransform diazepam, which is an anti anxiety agent (benzodiazepines), through the formation of its typical metabolites including temazepam, N-desmethyl-diazepam and oxazepam. This engineered liver construct is able to promote adhesion and to provide a microenvironment able to elicit specific cellular responses.
Acknowledgments The Authors acknowledge European Commission through the Livebiomat project, Contract No. NMP3-CT-2005-013653.
Page 1 and 2: ICOM 2008 Oral Presentation Proceed
Page 3 and 4: Professor Yoram Cohen Professor Joh
Page 5 and 6: ICOM 2008 Staff: The University of
Page 7 and 8: ICOM 2008 Workshop Schedule: Saturd
Page 9 and 10: Monday, July 14 - Afternoon Session
Page 11 and 12: Tuesday, July 15 - Afternoon Sessio
Page 13 and 14: 8:15AM 8:35AM EMS Barrer Prize (Mau
Page 15 and 16: Friday, July 18 - Morning Sessions
Page 17 and 18: Oral Presentation Abstracts Morning
Page 19 and 20: Gas Separation I - 1 - Keynote Mond
Page 21 and 22: esulting permeability selectivity o
Page 23 and 24: chain packing. To ensure a well pha
Page 25 and 26: Gas Separation I - 5 Monday July 14
Page 27 and 28: satisfactory way the corresponding
Page 29 and 30: Drinking and Wastewater Application
Page 35 and 36: an adjusted water management in the
Page 37 and 38: prospect for new energy sources as
Page 39 and 40: oxygen removal to the desired pH. C
Page 41 and 42: (Cl - , SO4 2- , As(V)) and water t
Page 43 and 44: [1] R. Lima de Miranda, J. Kruse, K
Page 45 and 46: Polymeric Membranes I - 4 Monday Ju
Page 47 and 48: Polymeric Membranes I - 5 Monday Ju
Page 49 and 50: Biomedical and Biotechnology I - 1
Page 51: Biomedical and Biotechnology I - 2
Page 55 and 56: isolation of CD34+ cells was achiev
Page 57 and 58: Biomedical and Biotechnology I - 6
Page 59 and 60: membranes were then challenged with
Page 61 and 62: in crossflow mode operation were in
Page 63 and 64: hydroxide. For Mg/Ca = 0, the fouli
Page 65 and 66: improvement of filterability also t
Page 67 and 68: scale where fouling rates are commo
Page 69 and 70: observed in two subsequence phenome
Page 71 and 72: Membrane Modeling I - Fundamental A
Page 73 and 74: Membrane Modeling I - Fundamental A
Page 75 and 76: of the impact of the operating para
Page 77 and 78: Oral Presentation Abstracts Afterno
Page 79 and 80: Hybrid and Novel Processes I - 2 Mo
Page 81 and 82: Arora, M.B., J.A. Hestekin, S.W. Sn
Page 83 and 84: Conclusions Reverse electrodialysis
Page 85 and 86: energy recovery. This is a remarkab
Page 87 and 88: eaction with mediator due to the co
Page 89 and 90: Nanofiltration and Reverse Osmosis
Page 91 and 92: 4.3x10 -6 to 7.4x10 -6 cm 2 /s. Bas
Page 93 and 94: The development of these membranes
Page 95 and 96: permeability, defined as water perm
Page 97 and 98: supports including charged (PSF/SPE
Page 99 and 100: [4] L. M. Robeson, Journal of Membr
Page 101 and 102: y conventional polymers and provide
Page 103 and 104:
[3] P.M. Budd, K.J. Msayib, C.E. Ta
Page 105 and 106:
Nanostructured Membranes I - 5 Mond
Page 107 and 108:
Fuel Cells I - 1 Monday July 14, 2:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
investigated at first. As a result,
Page 117 and 118:
Desalination I - 2 Monday July 14,
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Composite Polymeric Membrane Format
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
NAMS Alan S. Michaels Award - 1a Tu
Page 137 and 138:
NAMS Alan S. Michaels Award - 2 Tue
Page 139 and 140:
opportunities for improving membran
Page 141 and 142:
NAMS Alan S. Michaels Award - 4b Tu
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Nanofiltration and Reverse Osmosis
Page 149 and 150:
Page 151 and 152:
[4] K. Vanherck et al. Accepted for
Page 153 and 154:
accumulation had a strong effect on
Page 155 and 156:
and, if so, to develop correlations
Page 157 and 158:
non-porous and porous membranes are
Page 159 and 160:
[2] Palmeri, J., Sandeaux, R. Sande
Page 161 and 162:
fouling. Information obtained from
Page 163 and 164:
This work performed under the auspi
Page 165 and 166:
etween Ru(bi-pyridine)3 2+ and meth
Page 167 and 168:
[1] M. Barboiu, C. Luca, C. Guizard
Page 169 and 170:
Nanostructured Membranes II - 5 Tue
Page 171 and 172:
Nanostructured Membranes II - 6 Tue
Page 173 and 174:
than 10 nm. XRD data suggest that t
Page 175 and 176:
Pervaporation and Vapor Permeation
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
ethanol/butanol (non solvent) combi
Page 187 and 188:
forward osmosis, the RO process is
Page 189 and 190:
Osmotically Driven Membrane Process
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
References: [1] Stupp, S. I.; Lebon
Page 199 and 200:
temperatures might bring about the
Page 201 and 202:
References [1] S. Benita, Microenca
Page 203 and 204:
solvent, were investigated (where a
Page 205 and 206:
ease of manipulation as this allows
Page 207 and 208:
Horizontal shrinkage does not have
Page 209 and 210:
Absorption of water was determined
Page 211 and 212:
Gas Separation II - 1 - Keynote Tue
Page 213 and 214:
Gas Separation II - 2 Tuesday July
Page 215 and 216:
concentration. These results are co
Page 217 and 218:
Gas Separation II - 5 Tuesday July
Page 219 and 220:
will be shown that homogeneous film
Page 221 and 222:
which can adsorb on the surface of
Page 223 and 224:
Drinking and Wastewater Application
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
were collected, the viable bacteria
Page 231 and 232:
pressure, and permporosimetry with
Page 233 and 234:
Inorganic Membranes I - 3 Tuesday J
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Membrane Fouling - UF & Water Treat
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Membrane Modeling II - Gas Separati
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
[10] Wang BG, Lv HL, Yang JC. Chem
Page 261 and 262:
Membrane and Surface Modification I
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Oral Presentation Abstracts Morning
Page 269 and 270:
Gas Separation III - 1 - Keynote We
Page 271 and 272:
Gas Separation III - 2 Wednesday Ju
Page 273 and 274:
separation was next blended with di
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Polymeric Membranes II - 1 - Keynot
Page 291 and 292:
Polymeric Membranes II - 3 Wednesda
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
5. Erdodi, G.; Kennedy, J. P.; Prog
Page 299 and 300:
observed for different locations in
Page 301 and 302:
Biomedical and Biotechnology II - 3
Page 303 and 304:
applied in the first two fields wil
Page 305 and 306:
distribution of SBMA units within t
Page 307 and 308:
5500 ppm (15 mM) was lowered to 30
Page 309 and 310:
increasing the effective size of th
Page 311 and 312:
etween 0 and 1), the automatic feed
Page 313 and 314:
Membrane Modeling III - Process Sim
Page 315 and 316:
Membrane Modeling III - Process Sim
Page 317 and 318:
models developed suggests that ther
Page 319 and 320:
start level has a huge impact on th
Page 321 and 322:
Ultra- and Microfiltration I - Tran
Page 323 and 324:
all three binary protein UF systems
Page 325 and 326:
Synthetic solutions of ±-lactalbum
Page 327 and 328:
Oral Presentation Abstracts Morning
Page 329 and 330:
Gas Separation IV - 2 Thursday July
Page 331 and 332:
Page 333 and 334:
Page 335 and 336:
6. T. C. Merkel, Z. He, I. Pinnau,
Page 337 and 338:
Page 339 and 340:
EMS Barrer Prize - 1b Thursday July
Page 341 and 342:
EMS Barrer Prize - 3 Thursday July
Page 343 and 344:
EMS Barrer Prize - 4b Thursday July
Page 345 and 346:
EMS Barrer Prize - 5 Thursday July
Page 347 and 348:
therapy options have been modelled
Page 349 and 350:
Ultra- and Microfiltration II - Pro
Page 351 and 352:
Page 353 and 354:
Page 355 and 356:
Page 357 and 358:
Page 359 and 360:
Page 361 and 362:
Page 363 and 364:
in the vicinity of the rising bubbl
Page 365 and 366:
of feed water ionic strength) on re
Page 367 and 368:
technology that has gained growing
Page 369 and 370:
Optimize polymeric membranes for sa
Page 371 and 372:
Page 373 and 374:
Page 375 and 376:
Page 377 and 378:
Inorganic Membranes II - 2 Thursday
Page 379 and 380:
confirms that the carbon dioxide pe
Page 381 and 382:
Page 383 and 384:
Page 385 and 386:
permeability, stability issues comp
Page 387 and 388:
Fuel Cells II - 2 Thursday July 17,
Page 389 and 390:
Page 391 and 392:
Page 393 and 394:
Page 395 and 396:
Page 397 and 398:
5. Conclusion In this work, the evo
Page 399 and 400:
Oral Presentation Abstracts Afterno
Page 401 and 402:
an essentially pure H2 product is c
Page 403 and 404:
In the presentation, we will presen
Page 405 and 406:
was observed, indicative of the sim
Page 407 and 408:
References Arora, M.B., J.A. Hestek
Page 409 and 410:
performance of fibers is analyzed a
Page 411 and 412:
Membrane Fouling III - RO & Biofoul
Page 413 and 414:
Page 415 and 416:
Page 417 and 418:
Page 419 and 420:
Page 421 and 422:
Page 423 and 424:
Page 425 and 426:
[4] H. Noureddini, Book of Abstract
Page 427 and 428:
component (PX, OX) separation via p
Page 429 and 430:
Generally these results were in goo
Page 431 and 432:
introduction of methyl groups into
Page 433 and 434:
separation quality (10 µS/cm) and
Page 435 and 436:
Desalination II - 3 Thursday July 1
Page 437 and 438:
drop are linearly related (although
Page 439 and 440:
antiscalant oxidation has been limi
Page 441 and 442:
Page 443 and 444:
Page 445 and 446:
oth 15±5 kDa, which suggests that
Page 447 and 448:
Atomic Force Microscopy (AFM), and
Page 449 and 450:
Page 451 and 452:
y single gas permeation experiments
Page 453 and 454:
PDMS toplayers were only partially
Page 455 and 456:
noting that cross-linking agents co
Page 457 and 458:
such extended parameter space in th
Page 459 and 460:
Hybrid Membranes - 6 Thursday July
Page 461 and 462:
Plenary Lecture III Friday July 18.
Page 463 and 464:
Gas Separation V - 1 - Keynote Frid
Page 465 and 466:
References: [1] H. Lin, E. Van Wagn
Page 467 and 468:
elative contributions of Fickian di
Page 469 and 470:
Gas Separation V - 4 Friday July 18
Page 471 and 472:
Gas Separation V - 6 Friday July 18
Page 473 and 474:
Electron Microscopy (TEM) analyses
Page 475 and 476:
- Hybrid RO train: A hybrid RO trai
Page 477 and 478:
Page 479 and 480:
Page 481 and 482:
concentration as well as on the sod
Page 483 and 484:
scaling deposits in the DCMD device
Page 485 and 486:
Silica colloidal solution with diff
Page 487 and 488:
Membrane Fouling IV - RO & Desalina
Page 489 and 490:
Page 491 and 492:
Page 493 and 494:
Page 495 and 496:
Polyacrylonitrile (PAN) UF membrane
Page 497 and 498:
Page 499 and 500:
the polymer dope was PEI (12 wt%),
Page 501 and 502:
Inorganic Membranes III - 1 - Keyno
Page 503 and 504:
Inorganic Membranes III - 2 Friday
Page 505 and 506:
Page 507 and 508:
Page 509 and 510:
Page 511 and 512:
CO2/H2 selectivity at high temperat
Page 513 and 514:
ammonia complexes in aqueous soluti
Page 515 and 516:
possible to have a membrane capable
Page 517 and 518:
fired boiler flue gas, SOx and merc
Page 519 and 520:
EPR/Ago/p-benzoquinone composite sh
Page 521 and 522:
elated to the presence of free elec
Page 523 and 524:
Page 525 and 526:
Page 527 and 528:
Page 529 and 530:
surroundings. When the temperature
Page 531 and 532:
that no absorbent was detected in t
Page 533 and 534:
days of filtration from 120 to 7-10
Page 535 and 536:
was performed to restore membrane f
Page 537 and 538:
with the SRT of 65 days, no correla
Page 539 and 540:
Results Critical flux measurements
Page 541 and 542:
MLSS is not directly proportional t
Page 543 and 544:
Fuel Cells III - 2 Friday July 18,
Page 545 and 546:
Fuel Cells III - 4 Friday July 18,
Page 547 and 548:
Ultra- and Microfiltration III - Me
Page 549 and 550:
Page 551 and 552:
Page 553 and 554:
Page 555 and 556:
can be deduced from the imaginary p
Page 557 and 558:
membranes. The analysis of the ligh
Page 559 and 560:
Membrane Contactors - 2 Friday July
Page 561 and 562:
absorption liquid in the pores of t
Page 563 and 564:
Page 565 and 566:
Page 567 and 568:
Packaging and Barrier Materials - 1
Page 569 and 570:
Page 571 and 572:
Page 573 and 574:
Historically, all the approaches de
Page 575:
show all

NAMS 2002 Workshop - ICOM 2008

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?